The effect of antioxidants on photochemical reaction of pefloxacin by UVB (290~320nm) was investigated and the possible mechanism of phototoxicity on the skin was also studied. The photodegradation of pefloxacin by UVB was suppressed by cysteine, redu...
The effect of antioxidants on photochemical reaction of pefloxacin by UVB (290~320nm) was investigated and the possible mechanism of phototoxicity on the skin was also studied. The photodegradation of pefloxacin by UVB was suppressed by cysteine, reduced glutathione and ascorbic acid, but was promoted by alpha-tocopherol. Squalene, accounts for more than 10% of skin surface lipids, was peroxidized by pefloxacin through both radical and singlet oxygen mechanism.