Alkyl thiosulfi(o)nate 화합물의 합성과 생리활성 = Synthesis and Biological Activities of Aklyl Thiosulfi(o)nates

다국어 초록 (Multilingual Abstract)

Alkyl thiosulfi(o)nates, analogs of allyl-2-propene-1-thiosulfinate isolated from Allium sativum and
having antibacterial activity, were chemically synthesized and their biological activities were investigated.
Alkyl thiosulfinates were prepared by oxidation of corresponding disulfides with organic
peroxy acid, while alkyl thiosulfonates could be obtained by oxidation of the alkyl thiosulfinates
using sodium periodate. All synthetic thiosulfi(o)nates showed antibacterial activity against Staphylococcus
aureus B33 and antifungal activitiy against Candida utilis ATCC42416. Further more synthetic
alkyl thiosulfonates displayed antioxidant activity and have also prevention effect of platelet
aggregation induced by collagen in rat.

다국어 초록 (Multilingual Abstract)

Alkyl thiosulfi(o)nates, analogs of allyl-2-propene-1-thiosulfinate isolated from Allium sativum and
having antibacterial activity, were chemically synthesized and their biological activities were investigated.
Alkyl thiosulfinates were prepared by oxidation of corresponding disulfides with organic
peroxy acid, while alkyl thiosulfonates could be obtained by oxidation of the alkyl thiosulfinates
using sodium periodate. All synthetic thiosulfi(o)nates showed antibacterial activity against Staphylococcus
aureus B33 and antifungal activitiy against Candida utilis ATCC42416. Further more synthetic
alkyl thiosulfonates displayed antioxidant activity and have also prevention effect of platelet
aggregation induced by collagen in rat.

참고문헌 (Reference)

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