1-(4-chloro-2-fluoro-5-propargyloxyphenyl)-3-thiourea 유도체의 제초활성과 분자 유사성 = Herbicidal Activity and Molecular Similarity of 1-(4-chloro-2- fluoro-5-propargyloxyphenyl)-3-thiourea Derivatives

다국어 초록 (Multilingual Abstract)

In the search for third generation herbicidal cyclic imide derivatives, the average values of herbicidal
activity (pI50) in vivo (pre-emergence) of 40 new peroxidizing herbicides, 1-(4-chloro-2-fluoro-
5-propargyloxyphenyl)thiourea derivatives (1-40) against rice plant (Orysa sativa) and barnyard
grass (Echinochlor crus-galli) were studied. The molecular similarity between protoporphyrinogen
IX (protogen) as the substrate of protox enzyme and Urea derivatives (1-40) was discussed quantitatively.
The diallyl (20) and 3-nitro substituent (33) showed the selective herbicidal activity
against barnyard grass. Allyl substituent (8) and their molecular similarity indice (S=0.81) showed
the highest levels of herbicidal activity (pI50=4.71). Also, similarity indices (S) and superimposed
volume (C) of protogen and aryl-substituents (21-40) showed good correlation.

다국어 초록 (Multilingual Abstract)

In the search for third generation herbicidal cyclic imide derivatives, the average values of herbicidal
activity (pI50) in vivo (pre-emergence) of 40 new peroxidizing herbicides, 1-(4-chloro-2-fluoro-
5-propargyloxyphenyl)thiourea derivatives (1-40) against rice plant (Orysa sativa) and barnyard
grass (Echinochlor crus-galli) were studied. The molecular similarity between protoporphyrinogen
IX (protogen) as the substrate of protox enzyme and Urea derivatives (1-40) was discussed quantitatively.
The diallyl (20) and 3-nitro substituent (33) showed the selective herbicidal activity
against barnyard grass. Allyl substituent (8) and their molecular similarity indice (S=0.81) showed
the highest levels of herbicidal activity (pI50=4.71). Also, similarity indices (S) and superimposed
volume (C) of protogen and aryl-substituents (21-40) showed good correlation.

참고문헌 (Reference)

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