치료 작용점으로서의 Epigenetic 조절자 = Epigenetic Controllers as a Therapeutic Target

다국어 초록 (Multilingual Abstract)

Epigenetic processes required DNA methylation and histone modification which are regulated by several classes of enzymes in the cells. Imbalances in histone acetylation and DNA methylation lead to an aberrant behavior of the cells in morphology, cell cycle, differentiation, and carcinogenesis. Thus, the enzymes regulating the reactions can be considered as a therapeutic target of epigenetic modification. Clinical trials designed to evaluate inhibitors of DNA methyltransferases and histone deacetylases at phase I or phase II are showing encouraging results in cancer patients. A growing number of genes that are silenced by epigenetic inactivation can be used as biomarkers to monitor the efficacy of epigentically- effective drugs. (Cancer Prev Res 10, 1-5, 2005)

참고문헌 (Reference)

1 "Triple analysis of the cancer epigenome an integrated microarray system for assessing gene expression" 2164-2171, 2003

2 "Tissue-specific nuclear architecture and gene expression regulated by SATB1" 34 : 42-51, 2003

3 "The retinoblastoma gene product interacts with maintenance human DNA(cytosine-5)methyltransferase and modulates its activity" 21 : 779-788, 2002

4 "The power and the promise of DNA methylation markers" 3 : 253-266, 2003

5 "Rett syndrome:methyl-CpG-binding protein2 mutations and phenotype-genotype correlations" 97 : 147-152, 2000

6 "Relevance of DNA methylation in the management of cancer" 4 : 351-358, 2003

7 "Reglation of distinct biological activities of the NF-κB transcription factor complex by acetylation" 81 : 549-557, 2003

8 "Mutations truncateing the EP300 acetylase in human cancers" 300-303, 2000

9 "Methylation-sensitive representational difference analysis and its application to cancer research" 131-141, 2003

10 "Inhibitor of histone deacetylation in the treatment of peripheral and cutaneous T-cell lymphoma" 2865-2868, 2001

11 "Histone acetyltransferases" 70 : 81-120, 2001

12 "Histone acetylation- mediated regulation of genes in leukemic cells" 39 : 1165-1175, 2003

13 "Essential function of histone deacetylase 1 in proliferation control and CDK inhibitor repression" 2672-2681, 2002

14 "Epigenomics and epigenetic therapy of cancer" 8 : 2002

15 "Epigenetic regulation of gene expression:how the genome integrates intrinsic and environmental signals" 33 : 245-254, 2003

16 "Epigenetic regulation of gene expression:how the genome integrates intrinsic and environmental signals" 33 : 245-254, 2003

17 "ETO,fusion partner in acute myeloid leukemia,represses transcription by interaction with the human N-CoR/mSin3/HDAC1 complex" 95 : 10860-10865, 1998

18 "Direct acetylation of the estrogen receptor a hinge region by p300 regulates transactivation and hormone sensitivity" 276 : 18375-18383, 2001

19 "DNMT2 is not required for de novo and maintenance methylation of viral DNA in embryonic stem cells" 26 : 2536-2540, 1998

20 "DNMT1forms a complex with RB,E2F and HDAC1 and represses transcription from E2F responsive promoters" 25 : 338-342, 2000

21 "DNMT1 is required to maintain CpG methylation and aberrant gene silencing in human cancer cells" 33 : 61-65, 2003

22 "DNA methyltransferase inhibitors-state of the art" 13 : 1699-1716, 2002

23 "DNA methylation as a cancer-specific biomarker:from molecules to populations" 983 : 286-297, 2003

24 "CpG island methylator phenotype in colorectal cancer" 96 : 8681-8686, 1999

25 "Co- operation and communication between the human maintenance and de novo DNA(cytosine-5)methyltransferases" 21 : 4183-4195, 2002