Impact of Impaired Renal Function on the Incidence of Atrial Fibrillation after Radiofrequency Ablation of Cavotricuspid Isthmus-dependent Atrial Flutter

다국어 초록 (Multilingual Abstract)

Background and Objectives: Atrial fibrillation (AF) occurs frequently after successful radiofrequency ablation (RFA) of cavotricuspidisthmus-dependent atrial flutter (CTI-AFL). Renal impairment has been implicated in the development of AF. The purpose of this study isto clarify the impact of impaired renal function on the incidence of AF after RFA of CTI-AFL.
Subjects and Methods: Between January 2001 and December 2013, 240 non-dialysis patients with no prior history of AF {mean age55.9±15.2 years old; male, 192 (80.0%)} who had undergone successful CTI-AFL ablation were included in the present study. The baselineestimated glomerular filtration rate was calculated, and patients were divided into those with impaired renal function (<60 mL/min/1.73m2) and those with preserved renal function (≥ 60 mL/min/1.73 m2). The incidence of AF was retrospectively analyzed.
Results: 69 (28.8%) patients experienced new onset AF during a median follow-up duration of 26 months (inter-quartile, 7–53). Theincidence of AF was significantly higher in patients with impaired renal function than in those with preserved renal function {13/25(52.0%) versus 56/215 (26.0%), log rank p=0.019}. Age, CHADS2 score, impaired renal function, and left atrial diameter were significantlyassociated with the incidence of AF in univariate Cox regression analysis. Multivariate analysis showed that age was the only significantpredictor of AF incidence (hazard ratio, 1.024; 95% confidence interval, 1.004–1.044, p=0.020).
Conclusion: Patients with impaired renal function may require careful attention for the incidence of new onset AF following successfulRFA of CTI-AFL

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