Reactive Orange 16 Dye를 이용한 청색광차단 기능의 하이드로겔 콘택트렌즈 제조 = Preparation of Blue-Light Blocking Hydrogel Contact Lenses Using Reactive Orange 16 Dye

다국어 초록 (Multilingual Abstract)

Purpose : Blue-light blocking dyes were chemically conjugated to the hydrogel contact lenses. Blue-light blocking properties of the resultant contact were investigated, and the amounts of attached dyes were quantified.
Methods : Vinyl sulfone-based Reactive Orange 16 Dyes were covalently conjugated to hydrogel contact lenses containing a considerable amount of alcohol groups. The investigation for blue-light blocking properties of the hydrogel lenses and the quantification for the amounts of attached dyes were performed using UV-vis spectrophotometer.
Results : The blue-light blocking Reactive Orange 16 Dyes were successfully conjugated to the hydrogel contact lenses. The resultant contact lenses exhibited good blue-light blocking properties according to the results of the UV-vis spectra investigation. Reactive Orange 16 Dye conjugated to contact lenses was quantified using Beer-Lambert's law, and the blue-light blocking rate of contact lenses could be controlled by adjusting the concentration of reactive dye.
Conclusion : In this study, a reactive dye with a blue-light blocking function was fixed to hydrogel contact lenses through chemical bonding, and their blue-light blocking function was analyzed. It was confirmed that as the concentration of the blue-light blocking dye increased in the chemical reaction, the blocking intensity in the blue light wavelength region between 380 and 500 nm and the amount of the conjugated dye also increased. The development of blue-light blocking contact lenses that can be mass-produced is expected to play an important role in the development of functional ophthalmic optical medical devices.

국문 초록 (Abstract)

목적 : 반응성 청색광차단 염료를 하이드로겔 콘택트렌즈에 화학적으로 고정시켰고, 제조된 콘택트렌즈의 청색광차단 기능의 분석 및 첨가된 염료를 정량하고자 한다.
방법 : Vinyl sulfone-기반의 반응성 염료인 Reactive Orange 16 Dye를 다량의 알콜 작용기를 함유하는 하이드로겔 콘택트렌즈에 화학적으로 결합시켰다. 콘택트렌즈의 청색광차단 특성 및 염료의 정량은 UV-vis spectrophotometer를 이용하여 확인하였다.
결과 : 청색광차단기능의 Reactive Orange 16 Dye가 성공적으로 하이드로겔 콘택트렌즈에 결합되었다.
UV-vis spectra 분석을 통해 염료를 함유한 콘택트렌즈들이 우수한 청색광차단 기능을 보임을 확인하였다.
Beer-Lambert의 법칙을 이용하여, 콘택트렌즈에 첨가된 Reactive Orange 16 Dye를 정량하였으며, 반응 염료의 농도 조절을 통해, 콘택트렌즈의 청색광차단율을 조절할 수 있었다.
결론 : 본 연구에서는 청색광차단 기능의 반응성 염료를 하이드로겔 콘택트렌즈에 화학적 결합을 통해 고정시키고, 청색광차단 기능을 분석하였다. 화학적 반응에서 청색광차단 염료의 농도가 증가할수록, 380~500 nm 사이의 청색광 파장 영역에서의 차단 세기와 첨가된 염료의 양이 같이 증가함을 확인하였다. 대량생산이 가능한 청색광차단 콘택트렌즈의 개발은 기능성 안광학의료기기 개발에 큰 역할을 할 것으로 기대된다.

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