운동에 의한 노화촉진마우스의 기억,학습장애에 관한 연구 = A Study of Memory and Learning Impariments of Sensence-Accelerated Mouse by Exercise Training

다국어 초록 (Multilingual Abstract)

This study was designed to evaluate and investigate the effect of exercise training on defense mechanism of chronic degenerative disease, aging, learning and memory impairments of senescence-accelerated mouse (SAM)P8 mice under the hypothesis that “Senile dementia may be prevented by exercises”. To evaluate the effects of exercise training on the experimental animal model, SAMP8 mice with learning and memory impairment were divided into two groups, the control group and exercise training groups performed with low(□O2max 25~33%), middle(□O2max 50%) and high(□O2max 66~75%). All SAMP8 mice were fed experimental diet ad libitum until 4 and 8 months, and died. Median and maximum lifespan in middle exercise group resulted in a significantly increased(23.5% and 18.7%, respectively), whereas these lifespan in high exercise group resulted in an unexpectedly decreased (13.5% and 12.1%, respectively) compared with control group. Body fat levels in 4 and 8 months of age were significantly decreased 43% to 51% in middle exercise group, whereas were remarkably deceased to 57% in high exercise group compared with control group. It is believed that extending effects of median and maximum lifespan may be effected by carolie restriction through the exercise training. Acetylcholine(ACh) levels were significantly increased 6.7% and 8.5% in middle and high exercise groups, but choline acetyltransferase(ChAT) activities were significantly increased 10.3% and 11.9%, respctively, in middle and high exercise groups. Acetylcholinesterase(AChE) acitivities in middle group only were significantly increased in 4 and 8 months of age compared with control group. These results suggest that proper and regular exercises such as middle group(□O2max 50%) may play an effective role in attenuating an oxygen radicals and their oxidative stresses, and may play an desirable role in improving a learning and memory impairments and preventing a senile dementia.