임신과 분만에 따른 흰쥐의 혈액내 유리불포화지방산, 인지질, Creatinine 및 Prostaglandin 함량의 변화 = Effect of Blood Concentrations of Free Unsaturated Fatty Acid, Phospholipid, Creatinine and Prostagladin on the Stages of Pregnancy and Parturition in Female Rats

다국어 초록 (Multilingual Abstract)

This study is designed to evaluate serum free unsaturated fatty acid, phospholipid, creatinine and prostaglandin concentrations to provide normal values for physiological barometers and preliminary information related to these chemical components on the stages of pregnancy and parturition in female rats.
Forty female rats are devided into 8 groups. One control group contains 5 intact, nonpregnant female rats and the other 5 pregnancy groups contains each of 5 pregnant rats which are 9, 12, 15, 18 and 21days after pregnancy. The remaining 2 parturition groups contain each of 5 postparturient rats which are 12 and 36 hours after parturition.
The results obtained are as follows ;
1. The mean concentrations of free unsaturated fatty acid in serum of the female rats ranges from 6. 47 to 8. 22 ㎎/dl. The level of pregnancy group that is 21days being lower.
2. The mean concentrations of phospholipid in serum of the female rats ranges from 86 to 105㎎/dl. There is no marked difference between all of these groups, especially the levels of 12 days after pregnancy group and 36 hours after parturition group are lower than those of other groups.
3. The mean concentrations of crecatinine in serum of the female rats ranges from 0.64 to 0.84 ㎎/dl. There is no marked difference between all of 8 groups and the levels of 21 days after pregnancy group are higher than those of other groups.
4. The mean concentrations of prostaglandin in blood of the female rats ranges from 324 to 1208 ph/㎖ and increase from 736 pg/㎖(18 days after pregnancy) to maximal levels of 1208 pg/㎖ immediately after parturition, and then decreased progressively. Especially, each mean concentration of prostaglandin on 9, 12, or 15 days after pregnancy and mean concentrations of 5 pregnant groups are lower than those of nonpregnant female rats.
5. It is suggested that serum concentrations of free unsaturated fatty acid, phospholipid and creatinine in female rats are not related to the stages of pregnancy and parturition but prostaglandin concentrations influence the initiation of parturition in this species.