신장혈류량에 대한 INDOMETHACIN 효과에 있어서 레닌-엔지오텐신계의 역할 = The Role of the Renin Angiotensin System in the Effect of Indomethacin on Renal Blood Flow

다국어 초록 (Multilingual Abstract)

Since prostaglandin stimulates renin release, it is possible that the effect of indomethacin on renal blood flow may be modified by the activity of the renin-angiotensin system. The aim of this study was, therefore, to evaluate the role of renin-angiotensin system in the effect of indomethacin on renal blood flow. To pursue the goal, the effect of indomethacin on renal blood flow was evaluated in 2 groups: In one group(n=5), the response of renal blood flow to indomethacin (3 mg/kg bolus IV) was followed for an hour. The dogs in the other group(n=5) were pretreated with captopril and angiotensin Ⅱ to maintain the systemic and intrarenal plasma level of angiotensin Ⅱ constant despite the changes in the plasma renin activity that may follow indomethacin adminstration. In the group with renin-angiotensin system intact, renal blood flow initially changed, in response to indomethacin, from 171±17 ml/min(resting state), 165±23 ml/min(10 min), and then to 168±23 ml/min(30 min), 170±20 ml/min). In the group with renin-angiotensin system blocked, renal blood flow and mean arterial pressure were maintained at pre-infusion level by adjusting infusion rate of angiotensin Ⅱ(168±14 ml/min),and renal blood flows measured 10, 30, 60 min after indomethacin administration were 164±17, 166±15, 166±13 ml/min, respectively. However, changes in renal blood flow in response to indomethacin were not statistically significant regardless of the renin-angiotensin system activity, at any time interval after indomethacin administration.
The above result indicates that indomethacin does not affect renal blood flow in the anesthetized dog in the euvolemic state, and it seem that a decrease in plasma concentration of angiotensin Ⅱ due to prostaglandin synthesis inhibition contributed little to the effect of indomethacin on renal blood flow.