This study summarizes the recent cutting-edge approaches for dentin regeneration that still do not offer adequate
solutions. Tertiary dentin is formed when odontoblasts are directly affected by various stimuli. Recent preclinical
studies have reported...
This study summarizes the recent cutting-edge approaches for dentin regeneration that still do not offer adequate
solutions. Tertiary dentin is formed when odontoblasts are directly affected by various stimuli. Recent preclinical
studies have reported that stimulation of the Wnt/β-catenin signaling pathway could facilitate the formation of
reparative dentin and thereby aid in the structural and functional development of the tertiary dentin. A range of
signaling pathways, including the Wnt/β-catenin pathway, is activated when dental tissues are damaged and the pulp
is exposed. The application of small molecules for dentin regeneration has been suggested as a drug repositioning
approach. This study reviews the role of Wnt signaling in tooth formation, particularly dentin formation and dentin
regeneration. In addition, the application of the drug repositioning strategy to facilitate the development of new drugs
for dentin regeneration has been discussed in this study.