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      KCI등재 SCIE SCOPUS

      Implementation of Visible monkey into general-purpose Monte Carlo codes: MCNP, PHITS, and Geant4

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      https://www.riss.kr/link?id=A108816715

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      다국어 초록 (Multilingual Abstract)

      Recently, a new monkey computational phantom, called Visible Monkey, was developed for non-ionizing radiation studies in animal research. In this study, we extended its applications to ionizing radiation studies by implementing the voxel model of the Visible Monkey into three general-purpose Monte Carlo (MC) codes: MCNP6, PHITS, and Geant4. The implementation work for MCNP and PHITS was conducted using the LATTICE, UNIVERSE, and FILL cards. The G4VNestedParameterisation class was used for Geant4. Then, organ dose coefficients (DCs) for idealized photon beams in the antero-posterior direction were calculated using the three codes and compared, showing excellent agreement (differences <3%). Additionally, organ DCs in other directions (postero-anterior, left-lateral, and right-lateral) were calculated and compared with those of the newborn and 1-year-old reference phantoms. Significant differences were observed (e.g., the stomach DC of the monkey was 5-fold greater than that of the 1-year-old phantom at 0.03 MeV) while the differences tended to decrease with increasing energy (mostly <20% at 10 MeV). The results of this study allows conducting MC simulations using the Visible Monkey to estimate organ-level doses, which should be valuable to support/ improve monkey experiments involving ionizing radiation exposures.
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      Recently, a new monkey computational phantom, called Visible Monkey, was developed for non-ionizing radiation studies in animal research. In this study, we extended its applications to ionizing radiation studies by implementing the voxel model of the ...

      Recently, a new monkey computational phantom, called Visible Monkey, was developed for non-ionizing radiation studies in animal research. In this study, we extended its applications to ionizing radiation studies by implementing the voxel model of the Visible Monkey into three general-purpose Monte Carlo (MC) codes: MCNP6, PHITS, and Geant4. The implementation work for MCNP and PHITS was conducted using the LATTICE, UNIVERSE, and FILL cards. The G4VNestedParameterisation class was used for Geant4. Then, organ dose coefficients (DCs) for idealized photon beams in the antero-posterior direction were calculated using the three codes and compared, showing excellent agreement (differences <3%). Additionally, organ DCs in other directions (postero-anterior, left-lateral, and right-lateral) were calculated and compared with those of the newborn and 1-year-old reference phantoms. Significant differences were observed (e.g., the stomach DC of the monkey was 5-fold greater than that of the 1-year-old phantom at 0.03 MeV) while the differences tended to decrease with increasing energy (mostly <20% at 10 MeV). The results of this study allows conducting MC simulations using the Visible Monkey to estimate organ-level doses, which should be valuable to support/ improve monkey experiments involving ionizing radiation exposures.

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      참고문헌 (Reference)

      1 A.L. Reed, "X-3 MCC, Medical Physics Calculations with MCNP: a Primer" Los Alamos National Laboratory 2007

      2 ICRP, "The 2007 recommendations of the international commission on radiological protection, ICRP publication 103" 37 : 1-332, 2007

      3 J. Melville, "SOME EFFECTS OF MIXED IONIZING RADIATIONS ON RHESUS PRIMATES EXPOSED UNDER LABORATORY CONDITIONS"

      4 정범선 ; 전창엽 ; 허재원 ; 정강진 ; 하동환 ; 곽규성 ; 박진서, "Rise of the Visible Monkey: Sectioned Images of Rhesus Monkey" 대한의학회 34 (34): 1-15, 2019

      5 J. Allison, "Recent developments in Geant4" Elsevier BV 835 : 186-225, 2016

      6 Chung Yoh Kim, "Posture-Transformed Monkey Phantoms Developed from a Visible Monkey" MDPI AG 11 (11): 4430-, 2021

      7 Michel Thiebaut de Schotten, "Monkey to human comparative anatomy of the frontal lobe association tracts" Elsevier BV 48 (48): 82-96, 2012

      8 A. O’Sullivan, "Metabolomic phenotyping validates the infant rhesus monkey as a model of human infant metabolism" 56 : 355-363, 2013

      9 C.A. Anderson, "MESH HUMAN PHANTOMS WITH MCNP, vol. 10"

      10 C. J. Werner, "MCNP Version 6.2 Release Notes"

      1 A.L. Reed, "X-3 MCC, Medical Physics Calculations with MCNP: a Primer" Los Alamos National Laboratory 2007

      2 ICRP, "The 2007 recommendations of the international commission on radiological protection, ICRP publication 103" 37 : 1-332, 2007

      3 J. Melville, "SOME EFFECTS OF MIXED IONIZING RADIATIONS ON RHESUS PRIMATES EXPOSED UNDER LABORATORY CONDITIONS"

      4 정범선 ; 전창엽 ; 허재원 ; 정강진 ; 하동환 ; 곽규성 ; 박진서, "Rise of the Visible Monkey: Sectioned Images of Rhesus Monkey" 대한의학회 34 (34): 1-15, 2019

      5 J. Allison, "Recent developments in Geant4" Elsevier BV 835 : 186-225, 2016

      6 Chung Yoh Kim, "Posture-Transformed Monkey Phantoms Developed from a Visible Monkey" MDPI AG 11 (11): 4430-, 2021

      7 Michel Thiebaut de Schotten, "Monkey to human comparative anatomy of the frontal lobe association tracts" Elsevier BV 48 (48): 82-96, 2012

      8 A. O’Sullivan, "Metabolomic phenotyping validates the infant rhesus monkey as a model of human infant metabolism" 56 : 355-363, 2013

      9 C.A. Anderson, "MESH HUMAN PHANTOMS WITH MCNP, vol. 10"

      10 C. J. Werner, "MCNP Version 6.2 Release Notes"

      11 David H. Wood, "Long-Term Mortality and Cancer Risk in Irradiated Rhesus Monkeys" JSTOR 126 (126): 132-140, 1991

      12 J. T. Lett, "Late Cataractogenesis in Rhesus Monkeys Irradiated with Protons and Radiogenic Cataract in Other Species" JSTOR 126 (126): 147-156, 1991

      13 J. T. Goorley, "Initial MCNP6 Release Overview - MCNP6 Version 1.0"

      14 C.H. Kim, "ICRP Publication 145: Adult Mesh-Type Reference Computational Phantoms" SAGE Publications 49 (49): 13-201, 2020

      15 W.E. Bolch, "ICRP Publication 143: Paediatric Reference Computational Phantoms" SAGE Publications 49 (49): 5-297, 2020

      16 S. Ohnishi, "Gxsview: geometry and cross section viewer for calculating radiation transport" 14 : 100681-, 2021

      17 "Features of Particle and Heavy Ion Transport code System (PHITS) version 3.02"

      18 J Schümann, "Efficient voxel navigation for proton therapy dose calculation in TOPAS and Geant4" IOP Publishing 57 (57): 3281-3293, 2012

      19 김정요 ; Ae-Kyoung Lee ; Hyung-Do Choi ; 박진서, "Dawn of the Visible Monkey: Segmentation of the Rhesus Monkey for 2D and 3D Applications" 대한의학회 35 (35): 1-11, 2020

      20 Yosuke Iwamoto, "Benchmark study of the recent version of the PHITS code" Informa UK Limited 54 (54): 617-635, 2017

      21 ICRP, "Adult Reference Computational Phantoms, ICRP publication 110" 39 : 1-166, 2009

      22 L. C. Stephens, "Acute and late radiation injury in rhesus monkey parotid glands. Evidence of interphase cell death" 124 : 469-478, 1986

      23 J. A. Scott, "$40.00, Photon, Electron, Proton and Neutron Interaction Data for Body Tissues" International Commission on Radiation Units and Measurements 1993

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