Mancozeb의 아급성 노출이 마우스의 면역병리학적 인자 및 비장세포 증식능에 미치는 영향 = Effects of Subacute Oral Administration of Mancozeb on the Immunopathological Parameters and Splenocytes Proliferation in Mice

다국어 초록 (Multilingual Abstract)

Mancozeb, a polymeric complex of zinc and manganese salts of ethylene bisthiocarbamate (EBDC), is used widely in agriculture as fungicides, insecticides, and herbicides Mancozeb can be occupationally and environmentally exposed to human and has been reported to induce estrogenic activity, therein it is considered as an endocune disrupter After female TCR mice were treated Mancozeb of ally at the doses of 250, 1,000 and 1,500 mg/kg/day for consecutive 30 day, we investigated the effects of Mancozeb on the immunopathological parameters (body-, thymus-, spleen-, liver- and kidny-weight, splenic cellularity, hematological parameters) and mitogen (Con A, LPS)-induced splenocyte proliferation (SP) Liver- and kidney- weight wete increased , but body- and thymus-weight, number of splenocytes and WBC were decreased, when compared with control group When splenocytes isolated from the mice exposed to Mancozeb for 30 days were cultured in presence of mitogens, the SP against Con A was significantly and dose-dependently decreased and the SP against LPS was also slightly decreased Our present results indicate that Subacute exposure of Mancozeb to mice might show immunotoxic effect.