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The effects of the members of the same nuclear receptor superfamily (all-trans retinoic acid (RA), thyroid hormone(T3) or hydrocortisone) on proliferation and differentiation in the SK-N-SH neuroblastoma (NB) cell lines were studied. NB cells were tre...
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RISS 인기검색어
Neuroblastoma 세포의 생존과 분화에 미치는 retinoic acid , thyroid hormone , 및 hydrocortisone 의 작용 = Effect of Retinoic Acid , Thyroid Hormone and Hydrocortisone on Viability and Differentiation in SK - N - SH Neuroblastoma Cell Lines
한글로보기https://www.riss.kr/link?id=A3135700
- 저자
- 발행기관
- 학술지명
- 권호사항
-
발행연도
2000
-
작성언어
-
-
KDC
500
-
등재정보
SCIE,SCOPUS,KCI등재
-
자료형태
학술저널
-
수록면
285-292(8쪽)
- 제공처
- 소장기관
-
0
상세조회 -
0
다운로드
부가정보
다국어 초록 (Multilingual Abstract)
The effects of the members of the same nuclear receptor superfamily (all-trans retinoic acid (RA), thyroid hormone(T3) or hydrocortisone) on proliferation and differentiation in the SK-N-SH neuroblastoma (NB) cell lines were studied. NB cells were treated with RA, T3, or hydrocortisone at concentration of 10^(-6)M or 10^(-8)M for 3 days or 7 days. RA induced concentration- and time-dependent morphologic differentiation(neurite outgrowth and microtubule-associated protein expression) and growth inhibition in NB cells. Treatment of 10^(-6)M T3 for 7 days increased viability and differentiation of NB cells. Treatment of 10^(-6)M hydrocortisone for 7 days increased viability of NB cells. Although these three effectors are members of the same receptor superfamily, the regulation of brain development may be carried out in a different manner.
The effects of the members of the same nuclear receptor superfamily (all-trans retinoic acid (RA), thyroid hormone(T3) or hydrocortisone) on proliferation and differentiation in the SK-N-SH neuroblastoma (NB) cell lines were studied. NB cells were treated with RA, T3, or hydrocortisone at concentration of 10^(-6)M or 10^(-8)M for 3 days or 7 days. RA induced concentration- and time-dependent morphologic differentiation(neurite outgrowth and microtubule-associated protein expression) and growth inhibition in NB cells. Treatment of 10^(-6)M T3 for 7 days increased viability and differentiation of NB cells. Treatment of 10^(-6)M hydrocortisone for 7 days increased viability of NB cells. Although these three effectors are members of the same receptor superfamily, the regulation of brain development may be carried out in a different manner.
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