대장암에서 림프절 전이의 위험인자 = Risk Factors of Lymph Node Metastasis in Colon Cancers

다국어 초록 (Multilingual Abstract)

Backgroud: Colonic and rectal cancers recently increase in incidence and motality in Korea. Although a variety of therapeutic modality has been applied, the result of therapy for the patients having lymph node metastases is not good. Especially the patient can have lymph node metastases in spite of early colonic and rectal cancer, and high recurrence rate is expected if non-radical therapy without adjuvent modality is applied to these patient in follow-up period. Therefore it is aimed to identify the risk factor affecting lymph node metastasis and to evaluate the possibility of the nodal metastases preoperatively and postoperatively.
Methods: This retrospective study of 463 patients having suffered lower anterior resection, Miles operation or colectomy for colonic or rectal adenocarcinoma. Invasiveness, size of the carcinoma, age, vascular invasion, lymphovascular invasion, perineural invasion , sex, and grade of the carcinoma was evaluated as the possible risk factors of lymph node metastases.
Results: Resected colonic and rectal adenocarcinoma reveals regional lymph node metastases in 46.3% cases. The nodal metastasis is statistically correlated with increase in tumor stage, tumor grade, and presence of lymphovascular and perineural invasion, and older age (p<0.05).
Conclusion: Invasiveness, tumor grade, age, presence of lymphovascular invasion and perineural invasion would be risk factors expecting the regional lymph node metastasis in the colonic and rectal cancers. Therapeutic modality should be determined especially in tumor stage more than T1 because regional lymph node metastasis is expected.

목차 (Table of Contents)

• 서론
• 연구대상 및 방법
• 1. 연구대상
• 2. 연구방법
• 3. 분석
• 결 과
• 1. 결장 및 직장 선암의 임상 병리학적 특징
• 2. 림프절 전이의 위험인자
• 고찰
• 결론
• 참고문헌

참고문헌 (Reference)

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