Ku is a protein which act as a repairing enzyme for the DNA double strand breaks (DSBs). It has a heterodimeric structure composed of two subunits, Ku70 and Ku86. The detail mechanism of Ku in DNA repair processes is still not unknown, but it is certa...
Ku is a protein which act as a repairing enzyme for the DNA double strand breaks (DSBs). It has a heterodimeric structure composed of two subunits, Ku70 and Ku86. The detail mechanism of Ku in DNA repair processes is still not unknown, but it is certain that Ku is a one of key protein in maintenance of chromosomal integrity and cell survival. Recent studies reported that dysfunction of Ku protein is related to the development of radioresistance in case of overexpression of Ku and tumorigenesis with Ku underexpression. As Ku may act as either a tumor suppressor or an oncoprotein, precise regulation of Ku function may be important for the tumor suppression. Ku may be used for the treatment of cancer to resist radiotherapy or chemotherapy.