개의 아토피성 피부염에 대한 피내반응 및 면역요법 = Intradermal skin tests and immunotherapy on canine atopic dermatitis

다국어 초록 (Multilingual Abstract)

Atopic dermatitis (atopy, allergic inhalant dermatitis, AD) is a chronic, inflammatory skin disease in which the patient becomes sensitized to environmental allergens. Canine AD is one of the most common pruritic skin diseases of dogs associated mainly with the development of IgE antibodies to environmental allergens. Canine AD has been classified as a type I hypersensitivity reaction. The age of onset of clinical signs in atopic dogs vanes from 1 and 3 years of age. The major clinical signs of canine AD is seasonal or nonseasonal prutitus involving the face, feet, anterior elbows, axilla and ventrum.
Cutaneous changes may be secondary to self-scratching, chewing or licking. Otitis externa, secondary bacterial or Malassezia infections is common findings. A tentative diagnosis of canine AD can be based on history, clinical signs, and laboratory tests to rule out other diseases (flea allergic dermatitis, scabies. bacterial folliculitis and Malassezia dermatitis). A definitive diagnosis of atopy may be made with major and minor diagnostic criteria. Conventional therapy of canine AD are shampooing and medication of antibiotics, systemic glucocorticoids and antihistamines. In recent, several reports have demonstrated therapeutic benifits of cyclosporine, pentoxifylline and misoprostol. When these therpies are ineffective or adverse effects for glucocorticoid therapy are considered, allergen-specific immunotherapy based on the results of intradermal skin tests (IDST) or serologic IgE tests can be a safe and effective option that provides efficacy in approximately 50∼80% of atopic dogs. It is very important to be realized by owners and clinicians that the goals of these therapies are not in complete cure but in controlling the clinical signs of canine AD.