As the cancer genome has been mapped, the genetic basis of disease has been progressively elucidated. This has led to a greater understanding of inherited cancer syndromes that result from germline mutations to somatic acquisition of mutations in canc...
As the cancer genome has been mapped, the genetic basis of disease has been progressively elucidated. This has led to a greater understanding of inherited cancer syndromes that result from germline mutations to somatic acquisition of mutations in cancers. Preventative or early detection strategies in people with inherited cancer susceptibility genes has led to a reduction in the death from certain cancers. Somatic cancer analysis has led to improved prognostic and predictive biomarkers as well as novel approaches to cancer therapy that result in improved outcomes. This presentation will review our current understanding of cancer genetics and will identify practical applications of this knowledge for general gynecologists.