흰쥐 재생간의 Alkaline Phosphatase 의 활성치 = Alkaline Phosphatase Activities of Regenerating Liver in Rats

다국어 초록 (Multilingual Abstract)

The studies on changes of hepatic and serum alkaline phosphatase activities in 70% hepatectomized rats were performed and also compared with the level of isozymes of serum alkaline phosphatase, serum total bilirubin, serum glutamic pyruvic transaminase and incorporation rates of amino acid mixture-^(14)C into hepatic and serum proteins in the same rats. After partial hepatectomy of the rats, hepatic alkaline phosphatase activities were significantly increased in the period of 0.5 to 6 days with its peak level on the second day and returned to normal after ten days. The alkaline phosphatase activities significantly increased in the serum of the same rats with its peak level on the second day and increased activities has sustained during the ten days. In non-hepatectomized rats intestinal isozyme of alkaline phosphatase was predominantly increased than the liver isozyme with 2 folds increase and the similar isozyme pattern was observed with absolutely increased level in hepatectomized rats. The activity of serum glutamic pyruvic transaminase also elevated from 12 hours to two days after partial hepatectomy in rats. No significant changes in serum total bilirubin contents were noted throughout the experiments. The incorporation rate of amino acid mixture-^(14)C into hepatic protein showed an immediate increase after partial hepatectomy and reached maximum after 24 hours and these levels continued to be high throughout the six days. The incorporation rate into serum total protein, on the other hand, significantly decreased in the regenerating stage. The most decreased level of total protein was seen on the second day.