암 환자의 가임력 보존 = Fertility preservation for patients with cancer

다국어 초록 (Multilingual Abstract)

Background: The survival rate of cancer patients is increasing owing to the early diagnosis and treatment methods. Radiotherapy and chemotherapy may cause serious complications, such as ovarian failure and infertility.
In particular, preservation of fertility in women of reproductive age with cancer could improve their quality of life as well as reduce social and psychological pain.
Current Concepts: Embryo or oocyte cryopreservation is a method of fertility preservation; however, it cannot be utilized by all women with cancer because of the complications of the condition and treatment method. Ovarian tissue cryopreservation and transplantation enables fertility preservation in those needing immediate cancer treatment, such as chemotherapy or radiotherapy, or those unqualified for ovarian stimulation. A recent review reported that frozen-thawed ovarian transplantation led to approximately 130 live births with a conception rate of approximately 30%. Endocrine function recovery occurred in 92.9% of the patients between 3.5 and 6.5 months after transplantation.
Discussion and Conclusion: In this study, we introduced various methods and strategies for improving the outcomes of ovarian tissue cryopreservation and transplantation. These results could serve as a reference for patients and clinicians to choose the best options for fertility preservation based on the patient’s current situation and condition.

참고문헌 (Reference)

1 Revel A, "Whole sheep ovary cryopreservation and transplantation" 82 : 1714-1715, 2004

2 So-Youn Kim ; Seul Ki Kim ; 이정렬 ; Teresa K. Woodruff, "Toward precision medicine for preserving fertility in cancer patients: existing and emerging fertility preservation options for women" 대한부인종양학회 27 (27): 1-18, 2016

3 Xu M, "Tissue-engineered follicles produce live, fertile offspring" 12 : 2739-2746, 2006

4 Plante M, "The vaginal radical trachelectomy : an update of a series of 125 cases and 106pregnancies" 121 : 290-297, 2011

5 Wallace WH, "The radiosensitivity of the human oocyte" 18 : 117-121, 2003

6 Li F, "Sphingosine-1-phosphate prevents chemotherapy-induced human primordial follicle death" 29 : 107-113, 2014

7 Armuand GM, "Sex differences in fertility-related information received by young adult cancer survivors" 30 : 2147-2153, 2012

8 Oktay K, "Robot-assisted laparoscopic transplantation of frozen-thawed ovarian tissue" 24 : 897-898, 2017

9 Donnez J, "Restoration of ovarian function after allografting of ovarian cortex between genetically non-identical sisters" 25 : 2489-2495, 2010

10 Donnez J, "Restoration of ovarian activity and pregnancy after transplantation of cryopreserved ovarian tissue : a review of 60cases of reimplantation" 99 : 1503-1513, 2013

11 Rosen A, "Psychosocial distress in young cancer survivors" 25 : 268-277, 2009

12 Palermo G, "Pregnancies after intracytoplasmic injection of single spermatozoon into an oocyte" 340 : 17-18, 1992

13 Friedman O, "Possible improvements in human ovarian grafting by various host and graft treatments" 27 : 474-482, 2012

14 Forman EJ, "Pilot survey of oncologists regarding treatment-related infertility and fertility preservation in female cancer patients" 54 : 203-207, 2009

15 Lee S, "Ovarian tissue cryopreservation and transplantation in a young patient with cervical cancer : the first successful case in Korea" 40 : 498-501, 2019

16 Bedaiwy MA, "Ovarian tissue banking for cancer patients : reduction of post-transplantation ischaemic injury : intact ovary freezing and transplantation" 19 : 1242-1244, 2004

17 Oktay K, "Ovarian protection during adjuvant chemotherapy" 372 : 2268-2269, 2015

18 Oktay K, "Ovarian function after transplantation of frozen, banked autologous ovarian tissue" 342 : 1919-, 2000

19 Donnez J, "Ovarian cortex transplantation : time to move on from experimental studies to open clinical application" 104 : 1097-1098, 2015

20 NCCN Guidelines for Patients, "Ovarian cancer" National Comprehensive Cancer Network

21 Jensen AK, "Outcomes of transplantations of cryopreserved ovarian tissue to 41 women in Denmark" 30 : 2838-2845, 2015

22 Sklar C, "Maintenance of ovarian function and risk of premature menopause related to cancer treatment" (34) : 25-27, 2005

23 Donnez J, "Livebirth after orthotopic transplantation of cryopreserved ovarian tissue" 364 : 1405-1410, 2004

24 Marnitz S, "Interindividual variability of lymph drainages in patients with cervical cancer. Implication on irradiation planning" 182 : 80-85, 2006

25 Xu M, "In vitro grown human ovarian follicles from cancer patients support oocyte growth" 24 : 2531-2540, 2009

26 Kawamura K, "Hippo signaling disruption and Akt stimulation of ovarian follicles for infertility treatment" 110 : 17474-17479, 2013

27 Moore HC, "Goserelin for ovarian protection during breastcancer adjuvant chemotherapy" 372 : 923-932, 2015

28 Howell S, "Gonadal damage from chemotherapy and radiotherapy" 27 : 927-943, 1998

29 Martinez-Madrid B, "Freeze-thawing intact human ovary with its vascular pedicle with a passive cooling device" 82 : 1390-1394, 2004

30 Meirow D, "Fertility preservation in cancer patients using stored ovarian tissue : clinical aspects" 15 : 536-547, 2008

31 Wallace WH, "Fertility preservation for young patients with cancer : who is at risk and what can be offered?" 6 : 209-218, 2005

32 Lee S, "Fertility preservation for patients with gynecologic malignancies : The Korean Society for Fertility Preservation clinical guidelines" 44 : 175-180, 2017

33 Kristensen SG, "Fertility preservation and refreezing of transplanted ovarian tissue-a potential new way of managing patients with low risk of malignant cell recurrence" 107 : 1206-1213, 2017

34 Pavone ME, "Female fertility preservation : a clinical perspective" 68 : 458-465, 2016

35 Donfack NJ, "Expectations and limitations of ovarian tissue transplantation" 25 : 391-403, 2017

36 Luyckx V, "Evaluation of cryopreserved ovarian tissue from prepubertal patients after long-term xenografting and exogenous stimulation" 100 : 1350-1357, 2013

37 Mazur P, "Equilibrium, quasi-equilibrium, and nonequilibrium freezing of mammalian embryos" 17 : 53-92, 1990

38 Dath C, "Endothelial cells are essential for ovarian stromal tissue restructuring after xenotransplantation of isolated ovarian stromal cells" 26 : 1431-1439, 2011

39 Lee S, "Does higher starting dose of FSH stimulation with letrozole improve fertility preservation outcomes in women with breast cancer?" 98 : 961-964, 2012

40 Oktay K, "Development of human primordial follicles to antral stages in SCID/hpg mice stimulated with follicle stimulating hormone" 13 : 1133-1138, 1998

41 Lee S, "Determinants of access to fertility preservation in women with breast cancer" 95 : 1932-1936, 2011

42 Gosden R, "Cryopreservation : a cold look at technology for fertility preservation" 96 : 264-268, 2011

43 American Cancer Society, "Cancer facts and figures 2016" American Cancer Society

44 Goodwin T, "Attitudes and practices of pediatric oncology providers regarding fertility issues" 48 : 80-85, 2007

45 Kim SS, "Assessment of long term endocrine function after transplantation of frozen-thawed human ovarian tissue to the heterotopic site : 10 year longitudinal follow-up study" 29 : 489-493, 2012

46 Vajta G, "Are programmable freezers still needed in the embryo laboratory? Review on vitrification" 12 : 779-796, 2006

47 Korea Central Cancer Registry, "Annual report of cancer statistics in Korea in 2014" Ministry of Health and Welfare 2014

48 Han HS, "Analysis of chemotherapy-induced amenorrhea rates by three different anthracycline and taxane containing regimens for early breast cancer" 115 : 335-342, 2009

49 Lee SJ, "American Society of Clinical Oncology recommendations on fertility preservation in cancer patients" 24 : 2917-2931, 2006

50 Kano M, "AMH/MIS as a contraceptive that protects the ovarian reserve during chemotherapy" 114 : E1688-, 2017

51 Silber SJ, "A series of monozygotic twins discordant for ovarian failure : ovary transplantation(cortical versus microvascular)and cryopreservation" 23 : 1531-1537, 2008