白鼠의 高脂血症에 蒼朴二陳湯이 미치는 影響 = A study on the effects of Changbakleezintang on hyperlipidemia induced by high lipid solid cholesterol coloid solution in Rats

국문 초록 (Abstract)

본 연구는 한국에서 최근 발병률이 증대되고 있는 名種 循環器系 疾患의 誘發因子로서 중요시 인식되는 高脂血症에 대한 한의학적 치료방법 및 치료방제에 대한 탐색에서 시도된 논문이다. 이에 저자는 韓醫學에서 高脂血症과 개념상 유사성이 많은 心痛 胸痺 정충 水腫 眩暈 喘證 中風 等의 範疇에 속하는 병증의 치법에 다용되는 化痰祛瘀의 治方中『症因脈治』에 收載된 蒼朴二陳湯이 痰飮治療의 基本方인 二陳湯과 除濕運脾의 作用이 있는 蒼朮과 行氣의 作用이 있는 厚朴으로 構成되어 있어 高脂血症의 治療에 有效할 것으로 理論的으로 기대되어 이를 實驗的으로 立證하기 위하여 高脂肪性食餌로 高脂血症을 야기한 白鼠에 蒼朴二陳湯을 投與시켜 血淸 total-cholesterol, triglyceride, HDL-cholestrol, phospholipid, β-lipoprotein 等의 含量變化 및 total-cholesterol 含量에 대한 HDL-cholesterol 含量의 比率變化와 total-cholesterol 含量에 對한 phospholipid 含量의 比率變化 等을 觀察한 바 유의한 결과를 얻었다. 따라서 蒼朴二陳湯은 白鼠의 高脂血症病態의 改善에 有意한 效果가 있는 것으로 認定되며 高血壓, 動脈硬化 및 이로 因한 中風 等에도 臨床的 應用이 可能할 것으로 思科된다.

다국어 초록 (Multilingual Abstract)

This study was done in order to investigate the effect of Changbakleezintang on hyperlipidemia.
Results:
1. The level of serum total cholesterol was decreased with the significance in the sample groups as compared with the control groups.
2. The level of serum HDL-cholesterol was increased with the significance in sample groups as compared with the control groups.
3. The level of serum phospholipid was increased with significance in Sample 1 group as compared with Control 1 group, but Sample 2 group did not show significance as compared with Control 2 group.
4. The level of serum β-lipoprotein was decreased with the significance in Control 1 group, but control 2 group did not show significance.
5. Rate of total cholesterol vs. HDL-cholesterol and total cholesterol vs. phospholipid were increased in the sample groups as compared with the control groups.
It is considered that Changbakleezintang respectively had recovering effect on the Hyperlipidemia induced by cholesterol in male rats. So it can be use to prevent and treat hyperlipidemia and related deseases.