Quercetin Supplement is Beneficial for Altering Lipid Metabolism and Antioxidant Enzyme Activities in the Middle of Ethanol Feeding in Rats

다국어 초록 (Multilingual Abstract)

??The current study examined the effect of quercetin supplements on the lipid-lowering and antioxidant metabolism in ethanol-fed rats, The control group(E₈) received ethanol only diet for 8 wks, whereas the other group(E₈Q₄) received a diet including quercetin supplementation(0.05%, wt/wt) for 4 wks while on the ethanol diet for 8wks. The hepatic alcohol dehydrogenase activity was significantly higher in the E₈Q₄ group than in the E₈ group. Supplementation with quercetin significantly elevated the HDL- cholesterol concentration, the HDL-C/total-C ratio, and lowered the atherogenic index(AI) compared to the E₈ group. The hepatic triglyceride and cholesterol contents were significantly lowered by the quercetin supplement compared to those of the control group. The hepatic HMG-CoA reductase and ACAT activities of the E₈Q₄group were significantly lower than those of the E₈ group. The overall potential for antioxidant defense was significantly enhanced by the quercetin supplement, as indicated by a decrease in plasma and hepatic TBARS levels. The hepatic GSH-Px and G6PD activities were significantly higher in theE₈Q₄ group compared to the E₈ group. The current results suggest that dietary quercetin leads to the inhibition of HMG-CoA reductase and ACAT, which in turn lowers cholesterol levels and normalizes antioxidant enzyme activities.

목차 (Table of Contents)

• INTRODUCTION
• MATERIALS AND METHODS
• RESULTS
• DISCUSSION
• Literature Cited