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      저항운동이 CNTF 유전자 다형성에 따른 하지의 운동단위 동원능력, 근기능 및 운동수행능력에 미치는 영향

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      https://www.riss.kr/link?id=A100577955

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      The purpose of this study was to identify the effects of resistance exercise on motor unit recruitment, muscularstrength, muscular endurance, and exercise performance acording to CNTF gene polymorphism. Thesubjects of this study covered 8 normal homozygote GG group and 10 mutation heterozygote and homozygoteGA/AA group according to CNTF gene polymorphism. They performed resistance exercise during 8weeks. Comparative analysis of the results following conclusions were obtained by measuring body compositionand muscular function variables. Muscle mass(p<.001), fat free mass(p<.001), and body fat(p<.001)significantly improved in the GG and GA/AA groups. SUMP area o fvastus medialis during isokinetic exerciseof 180°/sec(p<.05), peak torque per body weight of knee joint extensor durin gisokinetic exercise of60°/sec(p<.001), peak torque per body weight of knee joint extensor during isokinetic exercise of 180°/sec(p<.001), reaction rate(p<.01), vertical jump(p<.001), side step(p<.001), 50m running time(p<.01), significantlyimproved in the GG and GA/AA groups. The changes opf eak torque per body weight of knee join textensor during isokinetic exercise of 60°/sec(p<.05) in the GA/AA group were significant higher than in th eGG group. In summary, resistance exercise had positive effect on motor unit recruitment, muscular endurance,and exercise performance regardless of CNTF gene polymorphism.H owever, muscle strength showed thedifference according to CNTF gene polymorphism.
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      The purpose of this study was to identify the effects of resistance exercise on motor unit recruitment, muscularstrength, muscular endurance, and exercise performance acording to CNTF gene polymorphism. Thesubjects of this study covered 8 normal homoz...

      The purpose of this study was to identify the effects of resistance exercise on motor unit recruitment, muscularstrength, muscular endurance, and exercise performance acording to CNTF gene polymorphism. Thesubjects of this study covered 8 normal homozygote GG group and 10 mutation heterozygote and homozygoteGA/AA group according to CNTF gene polymorphism. They performed resistance exercise during 8weeks. Comparative analysis of the results following conclusions were obtained by measuring body compositionand muscular function variables. Muscle mass(p<.001), fat free mass(p<.001), and body fat(p<.001)significantly improved in the GG and GA/AA groups. SUMP area o fvastus medialis during isokinetic exerciseof 180°/sec(p<.05), peak torque per body weight of knee joint extensor durin gisokinetic exercise of60°/sec(p<.001), peak torque per body weight of knee joint extensor during isokinetic exercise of 180°/sec(p<.001), reaction rate(p<.01), vertical jump(p<.001), side step(p<.001), 50m running time(p<.01), significantlyimproved in the GG and GA/AA groups. The changes opf eak torque per body weight of knee join textensor during isokinetic exercise of 60°/sec(p<.05) in the GA/AA group were significant higher than in th eGG group. In summary, resistance exercise had positive effect on motor unit recruitment, muscular endurance,and exercise performance regardless of CNTF gene polymorphism.H owever, muscle strength showed thedifference according to CNTF gene polymorphism.

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      참고문헌 (Reference)

      1 RyosukeTakahashi, "한국인 Ciliary Neurotrophic Factor (CNTF) 유전자의 다형성" 대한체질인류학회 16 (16): 73-78, 2003

      2 박창열, "트레이닝 方法에 따른 跆拳道 선수의 反應時間, 敏捷性, 순발력" 한국스포츠리서치 17 (17): 485-498, 2006

      3 이재구, "대학 검도선수의 수준별 근력요인 및 CNTF 유전자 다형성의 특성" 한국체육과학회 21 (21): 1255-1264, 2012

      4 이한용, "근수축 형태별 MERAC에 의한 훈련과 훈련중단시 대퇴근력 변화에 미치는 영향" 명지대학교 대학원 1994

      5 Arking, D. E., "Variation in the ciliary neurotrophic factor gene and muscle strength in older Caucasian women" 54 (54): 823-826, 2006

      6 Helgren, M. E., "Trophic effect of ciliary neurotrophic factor on denervated skeletal muscle" 76 (76): 493-504, 1994

      7 Holtmann, B., "Triple knock-out of CNTF, LIF, and CT-1 defines cooperative and distinct roles of these neurotrophic factors for motoneuron maintenance and function" 25 (25): 1778-1787, 2005

      8 Buller, A. J., "Transformation of contraction speed in muscle following cross-reinnervation : dependence on muscle size" 8 (8): 504-516, 1987

      9 Connor, B., "The role of neuronal growth factors in neurodegenerative disorder of the human brain. Brain research" 27 (27): 1-39, 1998

      10 Conwit, R. A., "The relationship of motor unit size, firing rate and force" 110 : 1270-1275, 1999

      1 RyosukeTakahashi, "한국인 Ciliary Neurotrophic Factor (CNTF) 유전자의 다형성" 대한체질인류학회 16 (16): 73-78, 2003

      2 박창열, "트레이닝 方法에 따른 跆拳道 선수의 反應時間, 敏捷性, 순발력" 한국스포츠리서치 17 (17): 485-498, 2006

      3 이재구, "대학 검도선수의 수준별 근력요인 및 CNTF 유전자 다형성의 특성" 한국체육과학회 21 (21): 1255-1264, 2012

      4 이한용, "근수축 형태별 MERAC에 의한 훈련과 훈련중단시 대퇴근력 변화에 미치는 영향" 명지대학교 대학원 1994

      5 Arking, D. E., "Variation in the ciliary neurotrophic factor gene and muscle strength in older Caucasian women" 54 (54): 823-826, 2006

      6 Helgren, M. E., "Trophic effect of ciliary neurotrophic factor on denervated skeletal muscle" 76 (76): 493-504, 1994

      7 Holtmann, B., "Triple knock-out of CNTF, LIF, and CT-1 defines cooperative and distinct roles of these neurotrophic factors for motoneuron maintenance and function" 25 (25): 1778-1787, 2005

      8 Buller, A. J., "Transformation of contraction speed in muscle following cross-reinnervation : dependence on muscle size" 8 (8): 504-516, 1987

      9 Connor, B., "The role of neuronal growth factors in neurodegenerative disorder of the human brain. Brain research" 27 (27): 1-39, 1998

      10 Conwit, R. A., "The relationship of motor unit size, firing rate and force" 110 : 1270-1275, 1999

      11 Robin, A. C., "The relationship between ciliary neurotrophic factor(CNTF)genotype and motor unit physiology : preliminary studies" 5 (5): 1-14, 2005

      12 Conwit, R. A., "The relationship between ciliary neurotrophic factor(CNTF)genotype and motor unit physiology : preliminary studies" 5 (5): 1-14, 2005

      13 Kraemer, W. J., "The influence of muscle action on the acute growth hormone response to resistance exercise and short-term detraining" 11 (11): 75-83, 2001

      14 Rankinen, T., "The human gene map for performance and health-related fitness phenotypes : the 2003 update" 36 (36): 1451-1469, 2004

      15 Ip, N. Y., "The alpha component of the CNTF recepter is required for signaling and defines potential CNTF targets in the adult and during development" 10 (10): 89-102, 1993

      16 Arakawa, Y., "Survival effect of ciliary neurotrophic factor(CNTF)on chick embryonic motoneuron in culture : comparison with other neurotrophic factors and cytokines" 10 (10): 3507-3515, 1990

      17 Berger, R. A., "Strength improvement"

      18 Westcott, W. L., "Strength fitness: Physiological principles and training techniques" Allyn & Bacon 1982

      19 Johnston, A. P., "Resistance training, sarcopenia, and the mitochondrial theory of aging" 33 (33): 191-199, 2008

      20 Stöckli, K. A., "Regional distribution, developmental changes, and cellular localization of CNTF-mRNA and protein in the rat brain" 115 (115): 447-459, 1991

      21 De Mars, G., "Polymorphisms in the CNTF and CNTF receptor genes are associated with muscle strength in men and women" 102 : 1824-1831, 2007

      22 Lewin, G. R., "Physiology of the neurotrophins" 19 : 289-317, 1996

      23 Kraemer, W. J., "Physiological adaptations to resistance exercise. Implications for athletic conditioning" 6 (6): 246-256, 1988

      24 Hakkinen, K., "Neuromuscular and hormonal adaptations during strength and power training. A review" 29 (29): 9-26, 1989

      25 Wojtys, E. M., "Neuromuscular adaptations in isokinetic, isotonic, agility training programs" 24 (24): 187-192, 1996

      26 Moore, D. R., "Neuromuscular adaptations in human muscle following low intensity resistance training with vascular occlusion" 92 (92): 399-406, 2004

      27 Sale, D. G., "Neural adaptation to resistance training" 20 (20): 135-145, 1988

      28 Rose, S. J., "Muscle mutability. Part 1. General concepts and adaptations to altered patterns of use" 62 (62): 1773-1787, 1982

      29 Hughes, R. A., "Members of several gene families influence survival of rat motoneurons in vitro and in vivo" 36 (36): 663-671, 1993

      30 Banner, L. R., "Major changes in the expression of the mRNAs for cholinergic differentiation factor/leukemia inhibitory factor and its receptor after injury to adult peripheral nerves and ganglia" 91 (91): 7109-7113, 1994

      31 Giaccaglia, V., "Interaction between angiotensin converting enzyme insertion/ deletion genotype and exercise training on knee extensor strength in older individuals" 29 (29): 40-44, 2008

      32 Singh, M. A., "Insulin-like growth factor I in skeletal muscle after weight-lifting exercise in frail elders" 277 (277): 135-143, 1999

      33 Macarthur, D. G., "Genes and human elite athletic performance" 116 (116): 331-339, 2005

      34 Conwit, R. A., "Fatigue effects on motor unit activity during submazimal contractions" 81 : 1211-1216, 2000

      35 Haas, C. A., "Expression of CNTF/LIF-receptor components and activation of STAT3signaling in axotomizes facial motoneurons : evidence for a sequential postlesional function of the cytokines" 41 (41): 559-571, 1999

      36 William, D. M., "Exercise Physiology: Energy, Nutrition, and Human Performance" Lippincott williams & wilkins 2001

      37 Baechle, T. R., "Essentials of strength training and conditioning" National strength and conditioning association 2000

      38 Kraemer, W. J., "Endocrine responses to resistance exercise" 20 (20): 152-157, 1998

      39 Sahlen, A., "Effects of prolonged exercise on left ventricular mechanical synchrony in long-distance runners : importance of previous exposure to endurance races" 23 (23): 977-984, 2010

      40 Behringer, M., "Effect of Resistance Training in Children and Adolescents : A Meta-analysis" 126 (126): 1199-1210, 2010

      41 Zanoteli, E., "Deficiency of muscle alpha-actinin-3 is compatible with high muscle performance" 20 (20): 39-42, 2003

      42 Stashuk, D. W., "Decomposition and quantitative anlysis of clinical electromygraphic signals" 21 : 389-404, 1999

      43 Oppenheim, R. W., "Control of embryonic motoneuron survival in vivo by ciliary neurotrophic factor" 251 (251): 1616-1618, 1991

      44 Williams, A. G., "Circulating angiotensin converting enzyme activity is correlated with muscle strength" 37 (37): 944-948, 2005

      45 Jacob, A. C., "Ciliary neurotrophic factor(CNTF)genotype and body composition" 12 (12): 372-376, 2004

      46 Fraysse, B., "Ciliary neurotrophic factor prevents unweighting-induced functional changes in rat soleus muscle" 88 (88): 1623-1630, 2000

      47 Sendtner, M., "Ciliary neurotrophic factor prevents the degeneration of motor neurons after axotomy" 345 (345): 440-441, 1990

      48 Sendtner, M., "Ciliary neurotrophic factor prevents degeneration of motor neurons in mouse mutant progressive motor neuronopathy" 358 (358): 502-504, 1992

      49 Van Vught, P. W., "Ciliary neurotrophic factor null alleles are not a risk factor for Charcot-Marie-Tooth disease, hereditary neuropathy with pressure palsies and amyotrophic lateral sclerosis" 17 (17): 964-967, 2007

      50 Forger, N. G., "Ciliary neurotrophic factor maintains motoneurons and their target muscles in developing rats" 13 (13): 4720-4726, 1993

      51 Guillet, C., "Ciliary neurotrophic factor is a regulator of muscular strength in aging" 19 (19): 1257-1262, 1999

      52 Distefano, P. S., "Ciliary neurotrophic factor induces down-regulation of its receptor and desensitization of signal transduction pathways in vivo : non-equivalence with pharmacological activity" 271 (271): 22839-22846, 1996

      53 Kraemer, W. J., "Changes in hormonal concentrations after different heavy-resistance exercise protocols in womer" 75 (75): 594-604, 1993

      54 Pennica, D., "Cardiotrophin-1, a cytokine present in embryonic muscle, supports long-term survival of spinal motoneurons" 17 (17): 63-74, 1996

      55 Roth, S. M., "CNTF genotype is associated with muscular strength and quality in humans across the adult age span" 90 : 1205-2010, 2001

      56 Walsh, S., "CNTF 1357 G → A polymorphism and the muscle strength response to resistance training" 107 (107): 1235-1240, 2009

      57 Thompson, P. D., "Angiotensin-converting enzyme genotype and adherence to aerobic exercise training" 9 (9): 21-24, 2006

      58 Bandy, W. D., "Adaptation of skeletal muscle to resistance training" 12 (12): 248-255, 1990

      59 Mccall, G. E., "Acute and chronic hormonal responses to resistance training designed to promote muscle hypertrophy" 24 (24): 96-107, 1999

      60 Charbonneau, D. E., "ACE genotype and the muscle hypertrophic and strength responses to strength training" 40 (40): 677-683, 2008

      61 Pescatello, L. S., "ACE ID genotype and the muscle strength and size response to unilateral resistance training" 38 (38): 1074-1081, 2006

      62 Takahashi, R., "A null mutation in the human CNTF gene is not causally related to neurological diseases" 7 (7): 79-84, 1994

      63 ALS CNTF Treatment Study Group, "A double-blind placebo-controlled clinical trial of subcutaneous recombinant human ciliary neurotrophic factor (rHCNTF) in amyotrophic lateral sclerosis" 46 (46): 1244-1249, 1996

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      2021-01-01 평가 등재학술지 유지 (재인증) KCI등재
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      기준연도 WOS-KCI 통합IF(2년) KCIF(2년) KCIF(3년)
      2016 0.72 0.72 0.71
      KCIF(4년) KCIF(5년) 중심성지수(3년) 즉시성지수
      0.78 0.85 0.652 0.24
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