Human embryonic stem cells (hESCs), hold considerable promise as a source for cell-based therapeutics, can be maintained as undifferentiated stare in culture or differentiated into tissues representing all three germ layers. However, the highest risk ...
Human embryonic stem cells (hESCs), hold considerable promise as a source for cell-based therapeutics, can be maintained as undifferentiated stare in culture or differentiated into tissues representing all three germ layers. However, the highest risk in the clinical application upon transplantation of hESCs and human induced pluripotent stem cells (hiPCSs) is the possibility of the teratoma formation by residual undifferentiated cells after differentiation process. In this review, we will discuss the properties of undifferentiated hESCs regarding teratoma formation. distinguishable from their differentiated counterparts, and introduce current studies of removing residual undifferentiated cells which are necessary for further application of embryonic stem cells.