To evulate usefulness of application of MAST-CLA to identify allergens in children, authors conducted MAST-CLA allergen-specific IgE assay and collected allergy related symptoms in 88 pediatric allegic patients diagnosed at Soonchunhyand University Ch...
To evulate usefulness of application of MAST-CLA to identify allergens in children, authors conducted MAST-CLA allergen-specific IgE assay and collected allergy related symptoms in 88 pediatric allegic patients diagnosed at Soonchunhyand University Chunan Hospital during October 1998 through January 2000. The mean (SD) age of study subjects was 8.8(3.2) years. The frequent allergic symptoms were rhinorrhea (40.9%), nasal stuffiness(38.6%), cough(36.4%), sneezing(35.2%), and itching sensation(28.4%) in order. Among them, 56.8% revealed at least more than one allergen specific IgE by MAST-CLA. The three most frequent specific allergens were Dermatophagoides farinae(52.3%) Dermatophagies pteronyssinus(51.1%), and house dust(35.2%). The positive rate of allergen specific IgE was increased by increasing age(P<0.001). Among the symptoms the sneezing showed most high positive rate of allergen specific IgE(80.7%) and total IgE(80.7%). In multivariate analysis, significant odds ratios remained(adjusted OR-4.66, P=0.004). In conclusion, our data suggest that allergic symptoms are associated with allergen-specific IgE using MAST-CLA assay, which is an useful measure for identification of causative allergens in pediatric allergen patients.