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      위종양의 점액형에 대한 면역조직화학적 연구 = Immuhistochemical Study on Mucin Phenotype in Gastric Adenocarcinoma

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      https://www.riss.kr/link?id=A40009758

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      To investigate the relationship between mucin phenotypes and prognostic factors in gastric adenocarcinoma, immunohistochemical stainings against antibodies(Muc 5AC, Muc-6, Muc-2, CD10, HMG 45M1, and p53 were performed in 104 cases of adenocarcinomas of the stomach.
      The most frequently expressed mucin phenotype is mixed mucin phenotype, followed by gastric mucin phenotype and intestinal mucin phenotype. In terms of invasiveness and lymph node metastasis, gastric adenocarcinoma with mixed mucin phenotype seems to be more aggressive than those with gastric and intestinal mucin phenotypes. There is no significant difference in expression of p53 protein among three mucin phenotypes.
      These results suggest that mixed mucin phenotype is the most frequently expressed mucin phenotype in gastric adenocarcinomas and seems to be associated with aggressiveness.
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      To investigate the relationship between mucin phenotypes and prognostic factors in gastric adenocarcinoma, immunohistochemical stainings against antibodies(Muc 5AC, Muc-6, Muc-2, CD10, HMG 45M1, and p53 were performed in 104 cases of adenocarcinomas o...

      To investigate the relationship between mucin phenotypes and prognostic factors in gastric adenocarcinoma, immunohistochemical stainings against antibodies(Muc 5AC, Muc-6, Muc-2, CD10, HMG 45M1, and p53 were performed in 104 cases of adenocarcinomas of the stomach.
      The most frequently expressed mucin phenotype is mixed mucin phenotype, followed by gastric mucin phenotype and intestinal mucin phenotype. In terms of invasiveness and lymph node metastasis, gastric adenocarcinoma with mixed mucin phenotype seems to be more aggressive than those with gastric and intestinal mucin phenotypes. There is no significant difference in expression of p53 protein among three mucin phenotypes.
      These results suggest that mixed mucin phenotype is the most frequently expressed mucin phenotype in gastric adenocarcinomas and seems to be associated with aggressiveness.

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