Zr-pyrithion complex was prepared by reaction of sod-pyrithione soln and zirconyl chloride soln and the acute toxicity, eye irritation and a primary skin irritation tests were performed. The binding of Zr-pyrithione to the cellulose was studied. The a...
Zr-pyrithion complex was prepared by reaction of sod-pyrithione soln and zirconyl chloride soln and the acute toxicity, eye irritation and a primary skin irritation tests were performed. The binding of Zr-pyrithione to the cellulose was studied. The acute oral LD_50 of Zr-pyrithion complex in the mouse was found to be 5,000㎎/㎏. An eye irritation in rabbits with a 0.1㎖ of 10%-suspension of Zr-pyrithione was applied to the rabbit cornea and conjunctives and did not produce any signs of irritation. Zr-pyrithione was made on the shaved skin of raddits with a 0.5g single applications. No signs of erythema were found in any of the test areas. Cotton fabric, cellulose, by a two-bath process with zirconyl acetate and sod-pyrithion retained excellent bacteriostatic activity after eighteen launderings. One-bath treatments with a Zr-pyrithion complex produced antimicrobial activity that was initially extremely high but was less durable to laundering. The two-bath process appears to be a general method for durably binding small amounts of a compound to cellulose.