지구성 운동수행 향상을 위한 생화학적 연구

다국어 초록 (Multilingual Abstract)

It has been hypothesized that branched-chain amino acids(BCAA) supplementation can reduce uptake of tryptophan during prolonged exercise and delay central fatigue According to this hyporthesis supplementation with BCAA will improve physical performance However, exessive activation of BCAA metabolism could drain the carbon flux in the citric acid cycle by using 2-oxoglutarate as an amino group acceptor, leading to a reduced exercise performance
The purpose of this study, therefore, was to verify the effects of BCAA plus ormthme α-ketoglutarate(OKG)trial compared to only BCAA trial on the concentration of plasma amino acids, brain tryptophan and on endurance performance in rats To achieve the purpose, an experiment was carry out as the followings Male Sprague-Dawley rats(200-250g) were randomly assigned on four groups, control group(GⅠ) and exercise group with water(5㎖, GⅡ), with BCAA(03g/100g body wt. dissolved in 5㎖ water, GⅢ), with BCAA plus OKG(each 03g/100g body wt dissolved in 5㎖ water, GⅣ) BCAA composition was 35%, 25% and 40% for leucine, isoleucme and valine OKG composition was 64%, 36% for ornithine and α-ketoglutarate Rats(GⅡ, Ⅲ, Ⅳ) were run after oral admonistration with each treatment to exhaustion on a horizontal animal treadmill at a speed of 25m/min Plasma amino acids in alxlominal aorta and tryptophan concentration in whole brain at the moment of exhaustion was collected The brain concentration of GⅢ(2 68±0 16㎍/g wet wt) was significantly lower(p<0 01) than that of GⅡ(6 01±0 09㎍/g wet wt), but not different with GⅣ(2 66±0 16㎍/g wet wt)
The concentration ratio of plasma tryptophan to BCAA of GⅢ(0 0483±0 0050) was significantly lower(p<0 05) than those of GⅡ(0 1495±0 0070) and GⅠ(0 0991±0 0060), but not different with GⅣ(0 0529±0 0054) Also, the concentration ratio of plasma tryptophan to BCAA+tyrosine+phenylalanine of GⅡ(0 1088±0 0070) was significantly higher(p<0 05) than those of GⅠ(0 0801±0 0040), GⅢ(0 0425±0 0030) and GⅣ(0 0461±0 0023) Time to exhaustion was not significantly different among three groups(GⅡ, 116 63±7 45, GⅢ, 101 20±8 57, GⅣ, 119 71±10 05min) The concentration of glutamate of GⅣ(62 00±6 75umol/l) was significantly higher(p<0 001) than those of three groups, and but not different with GⅡ(25 52±1 80umol/l) and GⅢ(17 30±0 87umol/l) From the results, it is verfied that although the concentration ratio of plasma free tryptophan to BCAA and brain concentration of tryptophan decreased in the BCAA trial, a positive effect of BCAA trial compared to water trial on endurance performance was not found Endurance performance in the simultaneous administration of BCAA and OKG had a trend of increase as compared to BCAA trial
These data suggest that the simultaneous administration of BCAA and OKG can have the effect of ergogenic aids long distance events

목차 (Table of Contents)

• Branched-chain amino acids와 ornithine α-ketoglutarate 의혼합투여가 흰쥐의 혈장 아미노산,뇌 트립토판 농도 및 지구성 운동 수행에 미치는 효과
• ABSTRACT
• Ⅰ.서론
• Ⅱ.연구방법
• Ⅲ.연구결과
• Ⅳ.논의
• Ⅴ.결론
• 참고문헌
• Branched-chain amino acids와 ornithine α-ketoglutarate 투여가 자각적 피로도 및 지구성 운동 수행에 미치는 효과
• Ⅰ.서론
• Ⅱ.연구방법
• Ⅲ.연구결과
• Ⅳ.논의
• Ⅴ.결론
• 참고문헌