간세포암의 근치적 절제술 후 실제 5년 생존율

다국어 초록 (Multilingual Abstract)

Purpose: After curative resection for hepatocellular carcinoma
(HCC), the five-year survival rate ranges between 30∼
50%; however, this might be different from the actual survival
rate. The actual 5-year survival rate and prognostic factors
following curative resection for HCC were analyzed.
Methods: A retrospective analysis was performed on 63 HCC
patients, who had undergone curative resection, between
1998 and 1999.
Results: A total of 63 cases, including 53 men and 10
women, were reviewed. The median age was 49 years old.
Pathologic T stage I, II, III and IV were observed in 1, 17,
38 and 7 cases, respectively. The actual 1-, 3- and 5-year
survival rates were 85.7, 69.8 and 57.0%, respectively, with
a median survival time of 58 months. The actual 1-, 3- and
5-year disease free survival rates were 68.1, 51.9 and 50.2%,
respectively, with a median disease free survival time of 46
months. Thirty-one patients had recurrence, mostly within one
year (65%), indicating a poor survival rate, with an actual
5-year survival rate of 5%. A satellite nodule, the pT stage,
recurrence of tumor, time to recurrence (within one year), and
presence of extrahepatic metastasis were found to be prognostic
factors influencing the survival rate of HCC patients.
However, microvessel invasion caused a difference in the
survival rate, but without statistical significance (p=0.08). A
satellite nodule, microvessel invasion and the pT stage were
found to be factors influencing the disease free survival rateof HCC patients. No statistically related factors, with the exception
of the pT stage, were found in a multivariate analysis.
Conclusion: The actual 5-year survival and disease free
survival rates were 57.0 and 50.2%, respectively. The time
to recurrence and pT stage were found to be factors influencing
the survival rate of patients with a hepatocellular
carcinoma. Further advanced studies will have to be carried
out for the active treatment of HCC cases with a pT stage
III or IV to reduce recurrence.

다국어 초록 (Multilingual Abstract)

Purpose: After curative resection for hepatocellular carcinoma
(HCC), the five-year survival rate ranges between 30∼
50%; however, this might be different from the actual survival
rate. The actual 5-year survival rate and prognostic factors
following curative resection for HCC were analyzed.
Methods: A retrospective analysis was performed on 63 HCC
patients, who had undergone curative resection, between
1998 and 1999.
Results: A total of 63 cases, including 53 men and 10
women, were reviewed. The median age was 49 years old.
Pathologic T stage I, II, III and IV were observed in 1, 17,
38 and 7 cases, respectively. The actual 1-, 3- and 5-year
survival rates were 85.7, 69.8 and 57.0%, respectively, with
a median survival time of 58 months. The actual 1-, 3- and
5-year disease free survival rates were 68.1, 51.9 and 50.2%,
respectively, with a median disease free survival time of 46
months. Thirty-one patients had recurrence, mostly within one
year (65%), indicating a poor survival rate, with an actual
5-year survival rate of 5%. A satellite nodule, the pT stage,
recurrence of tumor, time to recurrence (within one year), and
presence of extrahepatic metastasis were found to be prognostic
factors influencing the survival rate of HCC patients.
However, microvessel invasion caused a difference in the
survival rate, but without statistical significance (p=0.08). A
satellite nodule, microvessel invasion and the pT stage were
found to be factors influencing the disease free survival rateof HCC patients. No statistically related factors, with the exception
of the pT stage, were found in a multivariate analysis.
Conclusion: The actual 5-year survival and disease free
survival rates were 57.0 and 50.2%, respectively. The time
to recurrence and pT stage were found to be factors influencing
the survival rate of patients with a hepatocellular
carcinoma. Further advanced studies will have to be carried
out for the active treatment of HCC cases with a pT stage
III or IV to reduce recurrence.