Real-time Monitoring of Biomarkers: Current Status and Future Perspectives

다국어 초록 (Multilingual Abstract)

Real-time monitoring is a technique that can be accomplished in the future by continuous or high-frequency analyses of biomarkers indicating disorders (e.g., acute myocardial infarction) in an unattended manner, which eventually will occur in wearable or implantable biosensor formats (refer to Figure 1)1. This technique can enable early diagnosis and prognosis for target diseases, and even provide information related to the disease in progress and therapeutic effect in personalized medicine. The biochemical signs related to a disease will be combined with real-time physical signals such as cardiac impulse and pulsation, significantly increasing diagnostic accuracy2. A great number of disease-related biomarkers have been clinically validated, and various types of analytes from simple molecules, such as ions and metabolites, to large, complex markers, such as proteins and cells, are available. To achieve unattended care through real-time monitoring, unmet technical demands remained are as follows: 1) (semi-)continuous drawings of venous blood without pains and infection, 2) (semi-)continuous separation of blood cells, 3) recyclable immunosorbent, 4) miniaturized, possibly, label-free sensor system, 5) in situ baseline correction algorithm, and 6) secure data transmission.

참고문헌 (Reference)

1 Kim, D. H., "Semi-continuous, real-time monitoring of protein biomarker using a recyclable surface plasmon resonance sensor" 88 : 232-239, 2017

2 Rogers, M.L., "Real-time clinical monitoring of biomolecules" 6 : 427-453, 2013

3 Palmirotta, R., "Liquid biopsy of cancer: a multimodal diagnostic tool in clinical oncology" 10 : 2018

4 The Juvenile Diabetes Research Foundation Continuous Glucose Monitoring Study Group, "Continuous glucose monitoring and intensive treatment of type 1 diabetes" 359 : 1464-1476, 2008