Cyclosporine A 신독성에 미치는 칼슘길항제(Verapamil)의 효과에 대한 형태학적 연구 = Morphologic Effect of Calcium Channel-blocker(Verapamil) on Cyclosporine A Nephrotoxicity

다국어 초록 (Multilingual Abstract)

Effect of calcium channel blocker(CB) on cyclosporin A(C) nephrotoxicity was investigated in the Male Wister rat in a 4-week experiment at the light and electron microscopic level. To accomplish the aim of this study, 25 week old male Wister rats were divided into following 3 experimental groups ; 1CsA(50mg/kg/day) alone daily per os ; 2. CsA(5mg/kg/day) concomitant administration of CB verapamil(20mg/kg/day) daily per os; 3. CsA(50mg/kg/day) concomitant administration of verapamil(10mg/kg/day) daily per os.
Morphologically, CsA nephrotoxicity was characterized by the following features ; (1) tubular inclusion bodies corresponding to predominate polymerphous autolysosomes and a small number of markedly enlarged mitochondria ; (2) tubular vacuolization due to dilation of the rough and smooth endoplasmic reticulum ; (3) tubular microcalcification. These morphologic features were limited to the proximal tubules.
Simultaneous administration of CB verapamil with CsA reduced CsA induced morphologic damage of the proximal tubules of the kidney ; especially tubular inclusion bodies were significantly reduced, independent of the dosage of the verapamil.
These histopathological findings are interpreted as morphological manifestations of the effect of calcium channel blocker, verapamil ameliorating CsA nephrotoxicity