중추성 아세칠콜린 길항제가 조건변화에 따른 학습에 미치는 영향 = The Effects of Atropin Sulfate Upon the Task Requiring Conditional Operation

다국어 초록 (Multilingual Abstract)

The influence of atropin sulfate, an anticholinergic drug, upon a task in which subjects behaved conditionally was examined in two experiments. Subjects were albino rats. The task required that hungry rats learn to turn to the right in the illuminated condition and to the left in the unilluminated condition for food in the same T-maze. The first experiment investigated the effects of atropin sulfate upon the acquisition of the task and compared performance scores of three groups. These were administered atropin sulfate, methyl atropin and saline respectively.
The second experiment investigated the effects of atropin sulfate upon the retention of the same task requiring the conditional operation. For this we used different rats from those in the first experiment. After the rats were trained to reach the criterion, they were assigned to each of the three groups as specified above. They took a rest of one week and were retested. The results of the two experiments demonstrate that central cholinergic systems are important for the acquisition and retention of the conditional operation task. We can not however conclude with certainty that the effects of atropin sulfate upon acquisition and retention were due to the impairments of learning, because reaction time was also affected.