The Role of Oral Contraceptive Pills on Increased Risk of Breast Cancer in Iranian Populations: A Meta-analysis

다국어 초록 (Multilingual Abstract)

Background: Cancer is one of the main public health issues in the world. Breast cancer is one of the most common types of cancer among women. It is also the second cause of mortality in women. The association between the use of oral contraceptive pills and breast cancer is controversial and a main issue in public health. Some findings have shown that taking these pills does not have a significant effect in increasing the risk of breast cancer, while others have confirmed the carcinogenic effect of these products. These contradictory findings necessitated this meta-analysis, through of all correlated studies in Iran.
Methods: All published studies were considered from June 2000 until June 2015, using reliable Latin databases like PubMed, Google Scholar, Google search, Scopus, and Science Direct, and Persian database like SID, Irandoc, IranMedex, and Magiran. Finally, 26 papers were selected: 24 studies were case control while two were population based studies. A total of 26 papers with 46,260 participants were assessed since 2001.
Results: Overall estimate of OR for the effect of oral contraceptive pills on breast cancer is 1.521 (CI = 1.25-1.85), which shows that the intervention group had more chance (52%) compared to the control group (P = 0.001). Using these pills increased the risk of breast cancer up to 1.52 times.
Conclusions: Because of directly increasing levels of estrogen and the role of estrogen in gaining weight indirectly, oral contraceptive pills can stimulate the occurrence of breast cancer. More studies should be conducted for controlling the period of pill use.

참고문헌 (Reference)

1 Montazeri A, "Weight, height, body mass index and risk of breast cancer in postmenopausal women: a case-control study" 8 : 278-, 2008

2 Chen L, "The expression of CXCL13 and its relation to unfavorable clinical characteristics in young breast cancer" 13 : 168-, 2015

3 Yavari P, "The effects of reproductive factors on the risk of breast cancer, a study case - control" 1 : 9-11, 2006

4 Kihanian SH, "Survey risk factor of breast cancer at RAMSAR, TONKABON" 14 : 2010

5 Adib M, "Study risk factors related to medical history, lifestyle and Health behaviors of women with breast cancer patients Razi Hospital in the city of Rasht in 1388" 15 : 17-26, 2012

6 Emamimeybodi T, "Study on the relationship between breast cancer and female endocrine conditions, hormone therapy and oral contraceptive usage among women in Yazd, Iran during 2006-2007" 8 : 34-39, 2011

7 Holakoei N, "Study of risk factors for breast cancer in Mazandaran province in 1383" 4 : 27-36, 2006

8 Knottnerus A, "STROBE: a checklist to strengthen the reporting of observational studies in epidemiology" 61 : 323-, 2008

9 Veisy A, "Risk of breast cancer in relation to reproductive factors in North-West of Iran, 2013-2014" 16 : 451-455, 2015

10 Ebrahimi M, "Risk factors for breast cancer in Iran: a case-control study" 4 : R10-, 2002

11 Nelson HD, "Risk factors for breast cancer for women aged 40 to 49 years: a systematic review and meta-analysis" 156 : 635-648, 2012

12 Ghiasvand R, "Risk factors for breast cancer among young women in southern Iran" 129 : 1443-1449, 2011

13 Howell A, "Risk determination and prevention of breast cancer" 16 : 446-, 2014

14 Mina Hosseinzadeh, "Risk Factors for Breast Cancer in Iranian Women: A Hospital-Based Case-Control Study in Tabriz, Iran" 한국유방암학회 17 (17): 236-243, 2014

15 Nojomi MMR, "Relationship between hormonal factors and breast cancer" 7 : 19-25, 2004

16 Razmara L, "Relationship between fish consumption and decreased breast cancer risk" 9 : 307-316, 2010

17 Teegarden D, "Redefining the impact of nutrition on breast cancer incidence: is epigenetics involved?" 25 : 68-95, 2012

18 Coyle YM, "Physical activity as a negative modulator of estrogen-induced breast cancer" 19 : 1021-1029, 2008

19 Wingo PA, "Oral contraceptives and the risk of death from breast cancer" 110 : 793-800, 2007

20 Marchbanks PA, "Oral contraceptives and the risk of breast cancer" 346 : 2025-2032, 2002

21 Bassuk SS, "Oral contraceptives and menopausal hormone therapy: relative and attributable risks of cardiovascular disease, cancer, and other health outcomes" 25 : 193-200, 2015

22 Beaber EF, "Oral contraceptives and breast cancer risk overall and by molecular subtype among young women" 23 : 755-764, 2014

23 Kahlenborn C, "Oral contraceptive use as a risk factor for premenopausal breast cancer: a meta-analysis" 81 : 1290-1302, 2006

24 Vessey M, "Oral contraceptive use and cancer. Findings in a large cohort study, 1968-2004" 95 : 385-389, 2006

25 Marchbanks PA, "Oral contraceptive formulation and risk of breast cancer" 85 : 342-350, 2012

26 Scheen AJ, "Obesity, insulin resistance and type 2 diabetes: risk factors for breast cancer" 66 : 238-244, 2011

27 Dignam JJ, "Obesity and breast cancer prognosis:an expanding body of evidence" 15 : 850-851, 2004

28 Motie MR, "Modifiable risk of breast cancer in northeast iran: hope for the future. a case-control study" 6 : 453-456, 2011

29 Cleary MP, "Minireview: obesity and breast cancer:the estrogen connection" 150 : 2537-2542, 2009

30 Sutton AJ, "Methods for meta-analysis in medical research" John Wiley &Sons 2000

31 Whitehead A, "Meta-analysis of controlled clinical trials" John Wiley & Sons 2002

32 Ehsanpour S, "Investigation on the association between breast cancer and consumption patterns of combined oral contraceptive pills in the women of Isfahan in 2011" 18 : 186-190, 2011

33 Moradzadeh R, "Investigation on gene-environment interaction using breast cancer data a case-only and case-control designs" 10 : 267-278, 2011

34 Urban M, "Injectable and oral contraceptive use and cancers of the breast, cervix, ovary, and endometrium in black South African women:case-control study" 9 : e1001182-, 2012

35 Tazhibi M, "Hormonal and reproductive risk factors associated with breast cancer in Isfahan patients" 3 : 69-, 2014

36 Kashfi F, "Fertility risk factors causing breast cancer" 3 : 38-45, 2002

37 Pourfarzi F, "Factors affecting preferences of iranian women for breast cancer screening based on marketing mix components" 17 : 3939-3943, 2016

38 Javidi Z, "Evaluation of the relationship between pityriasis versicolor and consumption of oral contraceptives" 10 : 113-118, 2008

39 AttarParsaei F, "Evaluation of the relationship between demographic, social , lifestyle and stressors in women with breast cancer" 2 : 15-22, 2001

40 Tehranian NHF, "Evaluation of risk factors for breast cancer In women under 40 years" 16 : 37-44, 2009

41 Ghorbani A, "Evaluation of relationship between breast cancer and migraine" 4 : 14-, 2015

42 Eslamian G, "Dietary fiber, glycemic index, and glycemic load in relation to breast cancer in Iran" 2 : 82-88, 2013

43 Davis NM, "Deregulation of the EGFR/PI3K/PTEN/Akt/mTORC1 pathway in breast cancer: possibilities for therapeutic intervention" 5 : 4603-4650, 2014

44 Esfarjani S, "Comparative study of some breast cancer risk factors in patients with breast cancer and leukemia in Ahvaz Shafa Hospital" 9 : 263-270, 2010

45 Curado MP, "Cancer incidence in five continents, Vol IX" IARC Publications 2007

46 Ferlay J, "Cancer incidence and mortality worldwide: sources, methods and major patterns in GLOBOCAN 2012" 136 : E359-E386, 2015

47 DeSantis CE, "Breast cancer statistics, 2015: Convergence of incidence rates between black and white women" 66 : 31-42, 2016

48 Sepandi M, "Breast cancer risk factors in women participating in a breast screening program: a study on 11,850 Iranian females" 15 : 8499-8502, 2014

49 Lotfi MH, "Breast cancer risk factors in an urban area of Yazd City-Iran, 2006" 46 : 258-264, 2008

50 Ozmen V, "Breast cancer risk factors in Turkish women: a University Hospital based nested case control study" 7 : 37-, 2009

51 Pourzand A, "Breast cancer risk factors among women without family history in North West of Iran" 10 : 2013

52 Colditz GA, "Breast cancer risk accumulation starts early: prevention must also" 145 : 567-579, 2014

53 Yip CH, "Breast cancer in Asia" 471 : 51-64, 2009

54 Sharif Zadeh GR, "Breast cancer and the related factors: a case control study" 18 : 191-199, 2011

55 Onsory K, "Breast cancer and the effect of environmental factors involved" 1 : 59-70, 2011

56 Stephenson GD, "Breast cancer and obesity: an update" 45 : 1-16, 2003

57 Najf Zare, "Breast Cancer Risk Factors in a Defined Population: Weighted Logistic Regression Approach for Rare Events" 한국유방암학회 16 (16): 214-219, 2013

58 Tazhibi M, "Awareness levels about breast cancer risk factors, early warning signs, and screening and therapeutic approaches among Iranian adult women: a large population based study using latent class analysis" 2014 : 306352-, 2014

59 Allicock M, "African American women’s perspectives on breast cancer: implications for communicating risk of basal-like breast cancer" 24 : 753-767, 2013

60 Bethea TN, "A case-control analysis of oral contraceptive use and breast cancer subtypes in the African American Breast Cancer Epidemiology and Risk Consortium" 17 : 22-, 2015