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      KCI등재 SCOPUS

      Anti-inflammatory Activities of Lupane-triterpenoids In Vitro and Their Phytochemical Fingerprinting from Leaves of Acanthopanax gracilistylus

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      https://www.riss.kr/link?id=A103822469

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      다국어 초록 (Multilingual Abstract)

      The activities on the inhibition of NO on LPS-induced RAW 264.7 macrophages were investigated in this work. A simple and sensitive method has been developed and validated for fingerprinting analysis of leaves of Acanthopanax gracilistylus W.W. Smith (AGS). The cytotoxicity and inhibition of NO on LPS-induced RAW 264.7 cells of the extract and triterpenoids were determined. Optimal conditions of HPLC analysis were established as follows. The separation was performed with an ODS-C18 column at 30 oC, the detected wavelength was 210 nm, the flow rate was 1 mL/min, and the mobile phase consisted of acetonitrile (0.05% phosphoric acid) -0.05% phosphoric acid solution with gradient elution. Our results showed that impressic acid and acankoreaogenin was more effective on the inhibition of NO than the methanol extract and other compounds. There were seventeen peaks coexisted with similarities above 0.95 and nine lupane-triterpenoids including acankoreaogenin and impressic acid detected and identified. The result of anti-inflammatory activities provides a potential explanation for the use of AGS leaves as a herbal medicine in the treatment of inflammatory diseases. Our results also show that acankoreanogenin and impressic acid may be potentially useful in developing new anti-inflammatory agents. In addition, the fingerprint chromatography clearly illustrated and confirmed the material basis for the anti-inflammatory activities of this plant.
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      The activities on the inhibition of NO on LPS-induced RAW 264.7 macrophages were investigated in this work. A simple and sensitive method has been developed and validated for fingerprinting analysis of leaves of Acanthopanax gracilistylus W.W. Smith (...

      The activities on the inhibition of NO on LPS-induced RAW 264.7 macrophages were investigated in this work. A simple and sensitive method has been developed and validated for fingerprinting analysis of leaves of Acanthopanax gracilistylus W.W. Smith (AGS). The cytotoxicity and inhibition of NO on LPS-induced RAW 264.7 cells of the extract and triterpenoids were determined. Optimal conditions of HPLC analysis were established as follows. The separation was performed with an ODS-C18 column at 30 oC, the detected wavelength was 210 nm, the flow rate was 1 mL/min, and the mobile phase consisted of acetonitrile (0.05% phosphoric acid) -0.05% phosphoric acid solution with gradient elution. Our results showed that impressic acid and acankoreaogenin was more effective on the inhibition of NO than the methanol extract and other compounds. There were seventeen peaks coexisted with similarities above 0.95 and nine lupane-triterpenoids including acankoreaogenin and impressic acid detected and identified. The result of anti-inflammatory activities provides a potential explanation for the use of AGS leaves as a herbal medicine in the treatment of inflammatory diseases. Our results also show that acankoreanogenin and impressic acid may be potentially useful in developing new anti-inflammatory agents. In addition, the fingerprint chromatography clearly illustrated and confirmed the material basis for the anti-inflammatory activities of this plant.

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      참고문헌 (Reference)

      1 Zhang B. X, 11 : 1018-1023, 2011

      2 Piao, S. J, 22 : 230-235, 2011

      3 Niu, C, 35 : 2989-2996, 2011

      4 Liu, X. Q, Kyung Hee University 2003

      5 Yook, C. S, 50 : 1383-1385, 2002

      6 Nhiem, N. X, 57 : 986-989, 2009

      7 Liu, X. Q, 42 : 86-91, 2006

      8 Zou, Q. P, 47 : 120-126, 2011

      9 Wang, Y, 60 : 256-260, 2012

      10 Yuan, F, 15 : 210-215, 2009

      1 Zhang B. X, 11 : 1018-1023, 2011

      2 Piao, S. J, 22 : 230-235, 2011

      3 Niu, C, 35 : 2989-2996, 2011

      4 Liu, X. Q, Kyung Hee University 2003

      5 Yook, C. S, 50 : 1383-1385, 2002

      6 Nhiem, N. X, 57 : 986-989, 2009

      7 Liu, X. Q, 42 : 86-91, 2006

      8 Zou, Q. P, 47 : 120-126, 2011

      9 Wang, Y, 60 : 256-260, 2012

      10 Yuan, F, 15 : 210-215, 2009

      11 Duan, B, 35 : 513-518, 2012

      12 Jiang, B, 22 : 339-351, 2011

      13 Liao, H. J, 35 : 2193-2202, 2012

      14 Nie, H, 25 : 53-61, 2011

      15 Committee of Jiangsu New Medical College, "Traditional Chinese Medicine" Shanghai People’s Publishing House 380-, 1977

      16 Chinese Pharmacopoeia committee, "Pharmacopoeia of the People’s Republic of China" China Medical Science Press 61-, 2010

      17 Xiang-QianLiu, "A New Lupane-Triterpene Glycoside from the Leaves of Acanthopanax gracilistylus" 대한약학회 25 (25): 831-836, 2002

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      공동연구자 (7)

      유사연구자 (20) 활용도상위20명

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      학술지 이력

      학술지 이력
      연월일 이력구분 이력상세 등재구분
      2023 평가예정 해외DB학술지평가 신청대상 (해외등재 학술지 평가)
      2020-01-01 평가 등재학술지 유지 (해외등재 학술지 평가) KCI등재
      2011-01-01 평가 등재학술지 유지 (등재유지) KCI등재
      2009-01-01 평가 등재학술지 유지 (등재유지) KCI등재
      2006-01-01 평가 등재학술지 선정 (등재후보2차) KCI등재
      2005-01-01 평가 등재후보 1차 PASS (등재후보1차) KCI등재후보
      2003-07-01 평가 등재후보학술지 선정 (신규평가) KCI등재후보
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      학술지 인용정보

      학술지 인용정보
      기준연도 WOS-KCI 통합IF(2년) KCIF(2년) KCIF(3년)
      2016 0.18 0.18 0.16
      KCIF(4년) KCIF(5년) 중심성지수(3년) 즉시성지수
      0.15 0.15 0.359 0.02
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