A Study of the radioprotection effect of macro-glucan (β-1-3glucan) on thefetuses of ICR mice

다국어 초록 (Multilingual Abstract)

In this study abundant malformations of ICR mice in the organogenesis stages were observed and the radioprotection effect of Macro-Glucan(β-1-3glucan) was shown. This research examined the radioprotection effect of Macro-Glucan(β-1-3glucan) and its teratogenic properties. The reason it has a preventive effect on a tall fetus was examined in the research. We examined the determination stage (organogenesis), and pointed to malformation toward the radiation in the enviornmental agent to the malformaiton. Moreover, we examined the cellularis level of the embryos toward the radiation and analyzed the mechanism of the protection effect of the Macro-Glucan(-1-3glucan) from malformation induction by the radiation. Therefore, the purpose of this research is to get a foundation of data of the radioprotection effect of Macro-Glucan(-1-3glucan). This study produced the following results : It was made clear that Macro-Glucan(-1-3glucan) had a radioprotection effect against embryonic death. Radioprotection effect was recognized as the teratogenesis rate by Macro-Glucan(-1-3glucan)'s administering it before the exposure. Therefore, the subject faced radiation exposure by the Macro-Glucan(-1-3glucan) administration, and radiological protecting effect was made clear.