항암제로서의 TNF-Related Apoptosis-Inducing Ligands (TRAIL) = TNF-Related Apoptosis-Inducing Ligands (TRAIL) as a Therapeutic Agents in Cancer

다국어 초록 (Multilingual Abstract)

TRAIL have been widely viewed as potential cancer therapeutics because of its specific apoptosis- inducing capacity in tumor cells. The increased understanding of apoptosis pathways has directed attention to components of death receptor mediated apoptotic pathway as potential targets not only for chemotherapeutic but also for chemopreventive agents. An increasing number of previously identified chemotherapeutic and chemopreventive agents were found to increase the sensitivity to TRAIL-mediated apoptosis in a variety of premalignant and malignant cell types in vitro and in a few animal models in vivo. Also, phase 1 and 2 clinical trials using agonistic mAb that engage the human TRAIL receptor DR4 and DR5 have also provided encouraging results in cancer patients. Thus, understanding the control of death receptor-mediated apoptosis by chemotherapeutic and chemopreventive agents and their implications in cancer treatments may provide a rational approach for using such agents alone or in combination with TRAIL to enhance TRAIL-mediated apoptosis. In this study, we summarize biological agent and drug that sensitize tumors to TRAIL-mediated apoptosis and discuss the potential molecular basis for their sensitization. (Cancer Prev Res 11, 9-21, 2006)

참고문헌 (Reference)

1 "p53-independent upregulation of KILLER/DR5 TRAIL receptor expression by glucocorticoids and interferon-gamma" 262 : 154-169, 2001

2 "p53-dependent and -independent regulation of the death receptor KILLER/DR5 gene expression in response to genotoxic stress and tumor necrosis factor alpha" 58 : 1593-1598, 1998

3 "induces cell cycle arrest and apoptosis in HT29 human colon cancer cells" 60 : 1426-1433, 2000

4 "a novel class of potent and effective antitumor agents" 59 : 2615-2622, 1999

5 "Tumoricidal activity of tumor necrosis factor-related apoptosis- inducing ligand in vivo" 5 : 157-163, 1999

6 "Tumoricidal activity of a novel anti-human DR5 monoclonal antibody without hepatocyte cytotoxicity" 7 : 954-960, 2001

7 "Triptolide sensitizes resistant cholangiocarcinoma cells to TRAIL-induced apoptosis" 26 : 259-265, 2006

8 "The proteasome:a new target for novel drug therapies" 116 : 637-646, 2001

9 "The proteasome inhibitor bortezomib(PS-341)inhibits growth and induces apoptosis in primary effusion lymphoma cells" 4 : 77-82, 2005

10 "The proteasome inhibitor bortezomib sensitizes cells to killing by death receptor ligand TRAIL via BH3-only proteins Bik and Bim" 4 : 443-449, 2005

11 "The proteasome inhibitor PS-341 sensitizes neoplastic cells to TRAIL-mediated apoptosis by reducing levels of c-FLIP" 102 : 303-310, 2003

12 "The anti-tumor effect of Apo2L/ TRAIL on patient pancreatic adenocarcinomas grown as xenografts in SCID mice" 3 : 22-, 2005

13 "TRAIL/Apo2L ligand selectively induces apoptosis and overcomes drug resistance in multiple myeloma:therapeutic applications" 98 : 795-804, 2001

14 "TRAIL-induced apoptosis in gliomas is enhanced by Akt-inhibition and is independent of JNK activation" 10 : 233-243, 2005

15 "TRAIL and its receptors as targets for cancer therapy" 95 : 777-783, 2004

16 "Suppression of Fas/APO-1-mediated apoptosis by mitogen-activated kinase signaling" 160 : 2626-2636, 1998

17 "Sulforaphane sensitizes tumor necrosis factor-related apoptosis-inducing ligand(TRAIL)-resistant hepatoma cells to TRAIL-induced apoptosis through reactive oxygen species- mediated up-regulation of DR5" 66 : 1740-1750, 2006

18 "Sodium butyrate sensitizes TRAIL-mediated apoptosis by induction of transcription from the DR5 gene promoter through Sp1 sites in colon cancer cells" 25 : 1813-1820, 2004

19 "Sodium butyrate inhibits histone deacetylation in cultured cells" 1978 : 14-, 105-13

20 "Short-chain fatty acid-initiated cell cycle arrest and apoptosis of colonic epithelial cells is linked to mitochondrial function" 8 : 523-532, 1997

21 "Role of chemopreventive agents in cancer therapy" 215 : 129-140, 2004

22 "Requirement of p53 targets in chemosensitization of colonic carcinoma to death ligand therapy" 100 : 15095-15100, 2003

23 "Regula tion of apoptosis proteins in cancer cells by ubiquitin" 23 : 2009-2015, 2004

24 "Protein kinase C inhibition and x-linked inhibitor of apoptosis protein degradation contribute to the sensitization effect of luteolin on tumor necrosis factor- related apoptosis-inducing ligand-induced apoptosis in cancer cells" 65 : 7815-7823, 2005

25 "Proteasome inhibitors trigger NOXA- mediated apoptosis in melanoma and myeloma cells" 65 : 6282-6293, 2005

26 "Proteasome inhibitor MG132 upregulates death receptor 5 and cooperates with Apo2L/ TRAIL to induce apoptosis in Bax-proficient and -deficient cells" 23 : 2554-2558, 2004

27 "Proteasome inhibitor MG132 induces death receptor 5 through CCAAT/enhancer-binding protein homologous protein" 65 : 5662-5667, 2005

28 "Proteasome inhibition results in TRAIL sensitization of primary keratinocytes by removing the resistance- mediating block of effector caspase maturation" 23 : 777-790, 2003

29 "Proteasome inhibition in cancer:development of PS-341" 28 : 613-619, 2001

30 "Pretreatment of indole-3-carbinol augments TRAIL-induced apoptosis in a prostate cancer cell line, LNCaP" 544 : 246-251, 2003

31 "Pretreatment of acetylsalicylic acid promotes tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis by down-regulating BCL-2 gene expression" 280 : 41047-41056, 2005

32 "Preclinical studies to predict the disposition of Apo2L/tumor necrosis factor-related apoptosis-inducing ligand in humans: characterization of in vivo efficacy, pharmacokinetics, and safety." 299 : 31-38, 2001

33 "Potent induction of phase 2 enzymes in human prostate cells by sulforaphane" 10 : 949-954, 2001

34 "Potent antileukemic interactions between flavopiridol and TRAIL/ Apo2L involve flavopiridol-mediated XIAP downregulation" 18 : 1780-1788, 2004

35 "Phosphorylation-Based signaling in Fas receptor-mediated apoptosis" 20 : 121-152, 2000

36 "Phorbol 12-myristate 13-acetate inhibits death receptor-mediated apoptosis in Jurkat cells by disrupting recruitment of Fas-associated polypeptide with death domain" 277 : 3776-3783, 2002

37 "Molecular targets and anticancer potential of indole-3-carbinol and its derivatives" 4 : 1201-1215, 2005

38 "Mitochondrial-mediated disregulation of Ca21 is a critical determinant of Velcade(PS-341/bortezomib)cytotoxicity in myeloma cell lines" 65 : 3828-3836, 2005

39 "Mithramycin therapy in testicular cancer" 107 : 429-432, 1972

40 "Mithramycin in the treatment of Paget's disease of bone" 54 : 1730-1736, 1972

41 "Mithramycin forms a stable dimeric complex by chelating with Fe (II) DNA-interacting characteristics, cellular permeation and cytotoxicity" 33 : 1352-1361, 2005

42 "Mechanisms involved in development of resistance to adenovirus- mediated proapoptotic gene therapy in DLD1 human colon cancer cell line" 9 : 1262-1270, 2002

43 "MAPK/ ERK signaling in activated T cells inhibits CD95/Fas-mediated apoptosis downstream of DISC assembly" 19 : 5418-5428, 2000

44 "Luteolin inhibits vascular endothelial growth factor-induced angiogenesis; inhibition of endothelial cell survival and proliferation by targeting phosphatidylinositol 3'-kinase activity" 64 : 7936-7946, 2004

45 "Lessons from TRAIL-resistance mechanisms in colorectal cancer cells:paving the road to patient-tailored therapy" 7 : 345-358, 2005

46 "KILLER/DR5 is a DNA damage-inducible p53-regulated death receptor gene." 17 : 141-143, 1997

47 "Isotype-dependent inhibition of tumor growth in vivo by monoclonal antibodies to death receptor 4" 166 : 4891-4898, 2001

48 "Is apoptosis key in Alzheimer's disease" 281 : 1303-1304, 1998

49 "Irradiation specifically sensitises solid tumour cell lines to TRAIL mediated apoptosis" 5 : 5-, 2005

50 "Ionizing radiation enhances the therapeutic potential of TRAIL in prostate cancer in vitro and in vivo:intracellular mechanisms" 61 : 35-49, 2004

51 "Involvement of tumor necrosis factor-related apoptosis-inducing ligand in surveillance of tumor metastasis by liver natural killer cells" 7 : 94-100, 2001

52 "Involvement of Hsp90 in signaling and stability of 3-phosphoinositide-dependent kinase-1" 277 : 10346-10353, 2002

53 "Inhibitory effects of topical application of low doses of curcumin on 12-O-tetradecanoylphorbol-13-acetate-induced tumor promotion and oxidized DNA bases in mouse epidermis" 18 : 83-88, 1997

54 "Inhibitory effects of sodium salicylate and acetylsalicylic acid on UVB-induced mouse skin carcinogenesis" 11 : 1645-1652, 2002

55 "Inhibitory effect of curcumin and ferulic acid on tumor promotion in mouse skin by 12-O-tetradecanoylphorbol-13-acetate" 5941-5946, 1988

56 "Induction of tumor-specific T cell immunity by anti-DR5 antibody therapy" 199 : 437-448, 2004

57 "Induction apoptosis of luteolin in human hepatoma HepG2 cells involving mitochondria translocation of Bax/Bak and activation of JNK" 203 : 124-131, 2005

58 "Increased cyclooxygenase 2(COX-2)expression occurs frequently in precursor lesions of human adenocarcinoma of the lung" 30 : 73-81, 2000

59 "In vitro effects of topotecan and ionizing radiation on TRAIL/ Apo2L-mediated apoptosis in malignant glioma" 71 : 19-25, 2005

60 "Histone deacetylase inhibitor selectively induces p21WAF1 expression and gene-associated histone acetylation" 97 : 10014-10019, 2000

61 "HGS-ETR1, a fully human TRAIL-receptor 1 monoclonal antibody, induces cell death in multiple tumour types in vitro and in vivo." 92 : 1430-1441, 2005

62 "Growth inhibition,cell-cycle arrest and apoptosis in human T-cell leukemia by the isothiocyanate sulforaphane" 23 : 581-586, 2002

63 "Functional analysis of TRAIL receptors using monoclonal antibodies" 162 : 2597-2605, 1999

64 "Fruit and vegetable intakes and prostate cancer risk" 5 : 61-68, 2000

65 "FLICE- inhibitory proteins:regulators of death receptor-mediated apoptosis" 21 : 8247-8154, 2001

66 "Enhanced apoptosis and tumor regression induced by a direct agonist antibody to tumor necrosis factor-related apoptosis-inducing ligand receptor 2" 11 : 3126-3135, 2005

67 "Elimination of hepatic metastases of colon cancer cells via p53-independent cross-talk between irinotecan and Apo2 ligand/TRAIL" 64 : 9105-9114, 2004

68 "Effects of tumor necrosis factor-related apoptosis-inducing ligand alone and in combination with chemotherapeutic agents on patients' colon tumors grown in SCID mice" 62 : 5800-5806, 2002

69 "Effects of luteolin on the inhibition of proliferation and induction of apoptosis in human myeloid leukaemia cells" 16 : 295-298, 2002

70 "Effects of curcumin, demethoxycurcumin, bisdemethoxycurcumin and tetrahydrocurcumin on 12-O-tetradecanoylphorbol-13-acetate-induced tumor promotion." 16 : 2493-2497, 1995

71 "Effect of aspirin on induction of apoptosis in HT-29 human colon adenocarcinoma cells" 55 : 53-64, 1998

72 "Drug interactions between the proteasome inhibitor bortezomib and cytotoxic chemotherapy, tumor necrosis factor (TNF) alpha, and TNF-related apoptosis-inducing ligand in prostate cancer." 4537-4545, 2003

73 "Differential regulation of noxa in normal melanocytes and melanoma cells by proteasome inhibition:therapeutic implications" 65 : 6294-6304, 2005

74 "Death receptors in chemotherapy and cancer" 23 : 2950-2966, 2004

75 "Curcumin sensitizes tumor necrosis factor-related apoptosis- inducing ligand (TRAIL)-induced apoptosis through reactive oxygen species-mediated upregulation of death receptor 5 (DR5)." 1905 (1905): 2005

76 "Critical role for tumor necrosis factor-related apoptosis-inducing ligand in immune surveillance against tumor development" 195 : 161-169, 2002

77 "Combined effect of tumor necrosis factor-related apoptosis-inducing ligand and ionizing radiation in breast cancer therapy" 97 : 1754-1759, 2000

78 "Chemoprevention:an essential approach to controlling cancer" 2 : 537-543, 2002

79 "Chemoprevention of cancer" 21 : 525-530, 2000

80 "Cellular survival:a play in three Akts" 13 : 2905-2927, 1999

81 "CYP2E1- mediated mechanism of anti-genotoxicity of the broccoli constituent sulforaphane" 17 : 277-282, 1996

82 "Butyrate and the colonocyte. Production, absorption, metabolism, and therapeutic implications" 427 : 123-134, 1997

83 "Bortezomib abolishes tumor necrosis factorrelated apoptosis-inducing ligand resistance via a p21-dependent mechanism in human bladder and prostate cancer cells" 65 : 4902-4908, 2005

84 "Aspirin induced apoptosis in gastric cancer cells" 53 : 315-318, 1999

85 "Approaches to prevention of epithelial cancer during the preneoplastic period" 36 : 2699-2702, 1976

86 "Apoptosis induction in renal cell carcinoma by TRAIL and gamma-radiation is impaired by deficient caspase-9 cleavage" 88 : 1800-1807, 2003

87 "Apo2L/TRAIL: apoptosis signaling, biology, and potential for cancer therapy." 14 : 337-348, 2003

88 "Apo2L/TRAIL and its death and decoy receptors" 10 : 66-75, 2003

89 "Apo2 ligand/TNF-related apoptosisinducing ligand and death receptor 5 mediate the apoptotic signaling induced by ionizing radiation in leukemic cells" 60 : 5754-5760, 2000

90 "Apicidin, a histone deacetylase inhibitor, inhibits proliferation of tumor cells via induction of p21WAF1/Cip1 and gelsolin" 60 : 6068-6074, 2000

91 "Antiproliferative effect of curcumin(diferuloylmethane)against human breast tumor cell lines" 8 : 470-481, 1997

92 "Analysis of FasL and TRAIL induced apoptosis pathways in glioma cells" 20 : 5789-5798, 2001

93 "Activity of selective fully human agonistic antibodies to the TRAIL death receptors TRAIL-R1 and TRAIL-R2 in primary and cultured lymphoma cells: induction of apoptosis and enhancement of doxorubicin- and bortezomib-induced cell death" 130 : 501-510, 2005

94 "A synthetic inhibitor of histone deacetylase, MS-27-275, with marked in vivo antitumor activity against human tumors." 96 : 4592-4597, 1999

95 "17-allylamino-17-demethoxygeldanamycin synergistically potentiates tumor necrosis factor-induced lung cancer cell death by blocking the nuclear factor-kappaB pathway." 66 : 1089-1095, 2006