Gemfibrozil이 정상 성인의 기분 및 신경인지기능에 미치는 영향 = Effects of Gemfibrozil on Mood and Neurocognitive Functions in Normal Adults

다국어 초록 (Multilingual Abstract)

Objectives : Many studies have reported that the mood and cognitive functions are related to serum lipid concentration. The current study sought to determine whether gemfibrozil, lipid-lowering agent, affects mood and neurocognitive functions in normal adults.
Methods : Subjects were 15 healthy medical students and gemfibrozil of 600mg administered to them daily for 4 weeks. The levels of serum total cholesterol, high lipoprotein(HDL), low-density lipoprotein(LDL), and triglyceride were measured before the treatment and after 4weeks of the treatment. The depressive mood and anxiety were estimated from Beck Depression Inventory and Spielberger State and Trait Anxiety Inventory at the baseline and the 4th week. Neurocognitive functions were estimated from digit span test, digit symbol substitution test, finger tapping test, visual continuous performance test and cued test at the baseline and the 4th week.
Results : After four weeks, the subjects administered gemfibozil showed significant reductions in serum triglyceride levels(p=0.033), but other lipid levels did not show significant changes during the treatment. During gemfibrozil administration, no statistically significant changes were found in Beck Depression Inventory scales, Spielberger State and Trait Anxiety Inventory and other neurocognitive scales except for the digit symbol substitution test(p=0.000) between the baseline and following the 4th week.
Conclusions : Even though we need more well-controlled and long-term follow-up study in various and a large number of groups, these findings suggest that the gemfibrozil administration do not affect the mood and the neurocognitive functions comprehensively.

목차 (Table of Contents)

• 서론
• 연구 대상 및 방법
• 결과
• 고찰
• 요약