Targeting cancer energy metabolism: a potential systemic cure for cancer

다국어 초록 (Multilingual Abstract)

Long-term investigation and extensive efforts using sequencing and -omics analysis identified thousands of mutations in a single tumor. However, we cannot succeed at curing cancer by targeting mutations as the cause of cancer. Therefore, as an alternate therapeutic approach from classical oncology study, stimulation of the inherent ability of the immune system to attack tumor cells was welcome as a new principle in cancer therapy. However, it cannot be a permanent solution for the question of “which is the common factor that can distinguish cancer from normal?” Targeting the cancer energy metabolism may be a cancer-specific therapy for all kinds of cancer because normal cells do not rely on cancer energy metabolism under normal conditions. Here, trends of cancer metabolism as well as a new theory of cancer energy metabolism in the therapeutic approach is summarized.

참고문헌 (Reference)

1 Mathieu Paquette, "mTOR Pathways in Cancer and Autophagy" MDPI AG 10 (10): 18-, 2018

2 Rafael Moreno-Sánchez, "Who controls the ATP supply in cancer cells? Biochemistry lessons to understand cancer energy metabolism" Elsevier BV 50 : 10-23, 2014

3 Brett A. Wagner, "The rate of oxygen utilization by cells" Elsevier BV 51 (51): 700-712, 2011

4 Michael R. Stratton, "The cancer genome" Springer Science and Business Media LLC 458 (458): 719-724, 2009

5 David A. Fruman, "The PI3K Pathway in Human Disease" Elsevier BV 170 (170): 605-635, 2017

6 Natalya N. Pavlova, "The Emerging Hallmarks of Cancer Metabolism" Elsevier BV 23 (23): 27-47, 2016

7 Michele Visentin, "The Antifolates" Elsevier BV 26 (26): 629-648, 2012

8 Deep G, "Targeting tumor microenvironment with silibinin : promise and potential for a translational cancer chemopreventive strategy" 13 (13): 486-499, 2013

9 Pierre Sonveaux, "Targeting lactate-fueled respiration selectively kills hypoxic tumor cells in mice" American Society for Clinical Investigation 118 (118): 3930-3942, 2008

10 Filipa Morais-Santos, "Targeting lactate transport suppresses in vivo breast tumour growth" Impact Journals, LLC 6 (6): 19177-19189, 2015

11 Robert B. Hamanaka, "Targeting glucose metabolism for cancer therapy" Rockefeller University Press 209 (209): 211-215, 2012

12 Soohyun Lee, "Targeting Mitochondrial Oxidative Phosphorylation Abrogated Irinotecan Resistance in NSCLC" Springer Science and Business Media LLC 8 (8): 15707-, 2018

13 Yan Xiang, "Targeted inhibition of tumor-specific glutaminase diminishes cell-autonomous tumorigenesis" American Society for Clinical Investigation 125 (125): 2293-2306, 2015

14 Peter M. Wilson, "Standing the test of time: targeting thymidylate biosynthesis in cancer therapy" Springer Science and Business Media LLC 11 (11): 282-298, 2014

15 Lydia W.S. Finley, "SnapShot: Cancer Metabolism Pathways" Elsevier BV 17 (17): 466-466.e2, 2013

16 Francesco Lo-Coco, "Retinoic Acid and Arsenic Trioxide for Acute Promyelocytic Leukemia" Massachusetts Medical Society 369 (369): 111-121, 2013

17 Ming-Cheng Chen, "Resistance to irinotecan (CPT-11) activates epidermal growth factor receptor/nuclear factor kappa B and increases cellular metastasis and autophagy in LoVo colon cancer cells" Elsevier BV 349 (349): 51-60, 2014

18 Park J, "Regulation of bioenergetics through dual inhibition of aldehyde dehydrogenase and mitochondrial complex I suppresses glioblastoma tumorspheres" 20 (20): 954-965, 2018

19 Sarah F. Pearce, "Regulation of Mammalian Mitochondrial Gene Expression: Recent Advances" Elsevier BV 42 (42): 625-639, 2017

20 Reshma Rani, "Recent update on human lactate dehydrogenase enzyme 5 (hLDH5) inhibitors: a promising approach for cancer chemotherapy" American Chemical Society (ACS) 59 (59): 487-496, 2016

21 Taro Hitosugi, "Phosphoglycerate Mutase 1 Coordinates Glycolysis and Biosynthesis to Promote Tumor Growth" Elsevier BV 22 (22): 585-600, 2012

22 P. Yuan, "Phenformin enhances the therapeutic benefit of BRAFV600E inhibition in melanoma" Proceedings of the National Academy of Sciences 110 (110): 18226-18231, 2013

23 Johnson EA, "Phase III randomized, double-blind study of maintenance CAI or placebo in patients with advanced nonsmall cell lung cancer (NSCLC) after completion of initial therapy (NCCTG 97-24-51)." 60 (60): 200-207, 2008

24 Valerie S. LeBleu, "PGC-1α mediates mitochondrial biogenesis and oxidative phosphorylation in cancer cells to promote metastasis" Springer Science and Business Media LLC 16 (16): 992-1003, 2014

25 S Fujiwara, "PDK1 inhibition is a novel therapeutic target in multiple myeloma" Springer Science and Business Media LLC 108 (108): 170-178, 2013

26 Cantley LC, "Oncogenes and signal transduction" 64 (64): 281-302, 1991

27 민혜영, "Oncogene-Driven Metabolic Alterations in Cancer" 한국응용약물학회 26 (26): 45-56, 2018

28 Clementi E, "On the mechanism by which vascular endothelial cells regulate their oxygen consumption" 96 (96): 1559-1562, 1999

29 Weinhouse S, "On respiratory impairment in cancer cells" 124 (124): 267-269, 1956

30 Warburg O, "On respiratory impairment in cancer cells" 124 (124): 269-270, 1956

31 Tsuchida N, "Nucleotide sequence of the oncogene encoding the p21 transforming protein of Kirsten murine sarcoma virus" 217 (217): 937-939, 1982

32 Katarína Smolková, "Mitochondrial bioenergetic adaptations of breast cancer cells to aglycemia and hypoxia" Springer Science and Business Media LLC 42 (42): 55-67, 2010

33 Ed Reznik, "Mitochondrial DNA copy number variation across human cancers" eLife Sciences Publications, Ltd 5 : 2016

34 전지훈, "Migration and invasion of drug-resistant lung adenocarcinoma cells are dependent on mitochondrial activity" 생화학분자생물학회 48 : 1-9, 2016

35 Hong Xu, "Metformin Use Is Associated With Better Survival of Breast Cancer Patients With Diabetes: A Meta‐Analysis" Alphamed Press 20 (20): 1236-1244, 2015

36 Kıvanç Birsoy, "Metabolic determinants of cancer cell sensitivity to glucose limitation and biguanides" Springer Science and Business Media LLC 508 (508): 108-112, 2014

37 Christopher T. Hensley, "Metabolic Heterogeneity in Human Lung Tumors" Elsevier BV 164 (164): 681-694, 2016

38 Chi V. Dang, "MYC on the Path to Cancer" Elsevier BV 149 (149): 22-35, 2012

39 I. R. Schlaepfer, "Lipid Catabolism via CPT1 as a Therapeutic Target for Prostate Cancer" American Association for Cancer Research (AACR) 13 (13): 2361-2371, 2014

40 Brandon Faubert, "Lactate Metabolism in Human Lung Tumors" Elsevier BV 171 (171): 358-371.e9, 2017

41 Kim EH, "Inhibition of glioblastoma tumorspheres by combined treatment with 2-deoxyglucose and metformin" 19 (19): 197-207, 2017

42 Leah P. Shriver, "Inhibition of fatty acid metabolism ameliorates disease activity in an animal model of multiple sclerosis" Springer Science and Business Media LLC 1 (1): 2011

43 Lili Guo, "Inhibition of Mitochondrial Complex II by the Anticancer Agent Lonidamine" American Society for Biochemistry & Molecular Biology (ASBMB) 291 (291): 42-57, 2016

44 Matthew G. Vander Heiden, "Identification of small molecule inhibitors of pyruvate kinase M2" Elsevier BV 79 (79): 1118-1124, 2010

45 Christopher T. Hensley, "Glutamine and cancer: cell biology, physiology, and clinical opportunities" American Society for Clinical Investigation 123 (123): 3678-3684, 2013

46 Elwood JC, "Glucose utilization in homogenates of the morris hepatoma 5123 and related tumors" 23 : 906-913, 1963

47 Man Yu, "Generation, function and diagnostic value of mitochondrial DNA copy number alterations in human cancers" Elsevier BV 89 (89): 65-71, 2011

48 Ralph J. DeBerardinis, "Fundamentals of cancer metabolism" American Association for the Advancement of Science (AAAS) 2 (2): e1600200-, 2016

49 Richard Flavin, "Fatty acid synthase as a potential therapeutic target in cancer" Future Medicine Ltd 6 (6): 551-562, 2010

50 Ubaldo E. Martinez-Outschoorn, "Erratum: Cancer metabolism: a therapeutic perspective" Springer Science and Business Media LLC 14 (14): 113-113, 2017

51 Shawn M. Davidson, "Environment Impacts the Metabolic Dependencies of Ras-Driven Non-Small Cell Lung Cancer" Elsevier BV 23 (23): 517-528, 2016

52 J.-H. Cheong, "Dual Inhibition of Tumor Energy Pathway by 2-Deoxyglucose and Metformin Is Effective against a Broad Spectrum of Preclinical Cancer Models" American Association for Cancer Research (AACR) 10 (10): 2350-2362, 2011

53 El-Mir MY, "Dimethylbiguanide inhibits cell respiration via an indirect effect targeted on the respiratory chain complex I" 275 (275): 223-228, 2000

54 Guppy M, "Contribution by different fuels and metabolic pathways to the total ATP turnover of proliferating MCF-7 breast cancer cells" 364 (364): 309-315, 2002

55 Kristine Glunde, "Choline metabolism in malignant transformation" Springer Science and Business Media LLC 11 (11): 835-848, 2011

56 Anna Pastò, "Cancer stem cells from epithelial ovarian cancer patients privilege oxidative phosphorylation, and resist glucose deprivation" Impact Journals, LLC 5 (5): 4305-4319, 2014

57 김수열, "Cancer metabolism: targeting cancer universality" 대한약학회 38 (38): 229-301, 2015

58 Ubaldo E. Martinez-Outschoorn, "Cancer metabolism: a therapeutic perspective" Springer Science and Business Media LLC 14 (14): 11-31, 2017

59 Zu XL, "Cancer metabolism : facts, fantasy, and fiction" 313 (313): 459-465, 2004

60 Caitriona Holohan, "Cancer drug resistance: an evolving paradigm" Springer Science and Business Media LLC 13 (13): 714-726, 2013

61 김수열, "Cancer Metabolism: a Hope for Curing Cancer" 한국응용약물학회 26 (26): 1-3, 2018

62 김수열, "Cancer Metabolism: Strategic Diversion from Targeting Cancer Drivers to Targeting Cancer Suppliers" 한국응용약물학회 23 (23): 99-109, 2015

63 B. Vogelstein, "Cancer Genome Landscapes" American Association for the Advancement of Science (AAAS) 339 (339): 1546-1558, 2013

64 김수열, "Cancer Energy Metabolism: Shutting Power off Cancer Factory" 한국응용약물학회 26 (26): 39-44, 2018

65 Kallinowski F, "Blood flow, metabolism, cellular microenvironment, and growth rate of human tumor xenografts" 49 (49): 3759-3764, 1989

66 R. J. DeBerardinis, "Beyond aerobic glycolysis: Transformed cells can engage in glutamine metabolism that exceeds the requirement for protein and nucleotide synthesis" Proceedings of the National Academy of Sciences 104 (104): 19345-19350, 2007

67 Nixon GL, "Antimalarial pharmacology and therapeutics of atovaquone" 68 (68): 977-985, 2013

68 D. Rohle, "An Inhibitor of Mutant IDH1 Delays Growth and Promotes Differentiation of Glioma Cells" American Association for the Advancement of Science (AAAS) 340 (340): 626-630, 2013

69 강준희, "Aldehyde dehydrogenase is used by cancer cells for energy metabolism" 생화학분자생물학회 48 : 1-13, 2016

70 Kang JH, "Aldehyde dehydrogenase inhibition combined with phenformin treatment reversed NSCLC through ATP depletion" 7 (7): 49397-49410, 2016

71 Véronique Chajès, "Acetyl-CoA Carboxylase α Is Essential to Breast Cancer Cell Survival" American Association for Cancer Research (AACR) 66 (66): 5287-5294, 2006

72 Daniel E Bauer, "ATP citrate lyase is an important component of cell growth and transformation" Springer Science and Business Media LLC 24 (24): 6314-6322, 2005

73 Choi EJ, "A clinical drug library screen identifies clobetasol propionate as an NRF2 inhibitor with potential therapeutic efficacy in KEAP1 mutant lung cancer" 36 (36): 5285-5295, 2017

74 Jianjiong Gao, "3D clusters of somatic mutations in cancer reveal numerous rare mutations as functional targets" Springer Science and Business Media LLC 9 (9): 4-, 2017