급성 백혈병 환자의 비특이성 면역에 관한 연구 = Nonspecific Immune State in Acute Leukemia

다국어 초록 (Multilingual Abstract)

In this study, the authors investigated changes in the non-specific immune states of 35 acute leukemia patients(19 AML; 16 ALL) according to the state of their disease (25 at diagnosis; 10 in complete remission with three off-treatments) and compared them to those of normal controls. The natural killer(NK) cell activity aganist K562 target cells and antibody-dependent cellular cytotoxicity(ADCC) against L1210 target cells were measured by four-hour chromium release cytotoxic assays. The number of NK cells was estimated by immunofluorescence techniques using monoclonal antibodies of Leu-7a, while Leu-11 and T-cell subpopulations were estimated by monoclonal antibodies ctf CD3, CD4, CD8. Interleukin-2 (IL2) productivity was measured with peripheral mononuclear cells from five patients.
The results were as follows;
1) The NK and ADCC activities significantly decreased in the initial state, which might be due to a decreased number of NK cells and also to a diluting effect by the circulating blasts in ADCC.
2) In the complete remission state, patients who had maintenance chemotherapy showed a lower NK cell number, which resulted in decreased NK activity during this period without any effect on ADCC.
3) Compared to the controls, such depression of nonspecific immune state was more pronounced in the AML group than in the ALL group.
In conclusion, the non-specific cellular immune states differed between the initial state and the complete remission state, to which maintenance chemotherapy might be attributed. The mechanism and the clinical significance of such an altered immune state according to the diseased state in relation to maintenance treatment remain to be elucidated.