Comparison of exit site infection and peritonitis incidences between povidone-iodine and normal saline use for chronic exit site care in peritoneal dialysis patients = Comparison of exit site infection and peritonitis incidences between povidone-iodine and normal saline use for chronic exit site care in peritoneal dialysis patients

다국어 초록 (Multilingual Abstract)

Background: Catheter-related exit site infection is a major risk factor for thedevelopment of peritonitis and can contribute to failure of treatment maintenancein peritoneal dialysis (PD) patients. Although povidone-iodine can be used forexit site care, the irritation induced by the local application of povidone-iodinecould lead to secondary infection. Therefore, we evaluated the clinical effectivenessof normal saline compared with povidone-iodine as a method of exit site care inchronic PD patients. Methods: In all, 126 patients undergoing PD treatment for46 months betweenJanuary 2006 and December 2009 were enrolled. Data were retrospectivelyanalyzed for the incidence of exit site infection and peritonitis for 2 years prior toand after December 2007. In addition, we identified the incidences of catheterrelatedinfections during follow-ups from January 2010 to December 2013. Results: The participants`` mean age was 58.8712.9 years. The incidences of exitsite infection and peritonitis were one episode per 64.6 patients-months andone episode per 40.4 patients-months in the povidone-iodine group, respectively,whereas these were one episode per 57.5 patients-months and one episode per 45.6patients-months in the normal saline group, respectively. Whereas Gram-positivebacteria most frequently caused catheter-related infections in both groups, culturenegativeinfections were dominant in the normal saline group. Conclusion: Exit site care using normal saline did not increase the incidence ofexit site infection and peritonitis. Therefore, normal saline may be an alternativetreatment for exit site care in patients receiving PD.