Runx2는 runt gene family에 속하는 전사조절 인자로써 뼈의 형성과 골아세포의 분화에 중요한 역할을 담당하고 있다. Runx2-haploinsufficency는 쇄골의 저형성 및 두개 봉합의 지연을 특징으로 하는 쇄...
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https://www.riss.kr/link?id=A45001624
2004
Korean
치낭 ; 쇄골두개 이형성증 ; 치아발육 ; 치아맹출 ; Runx2 ; Dental follicle ; Cleidocranial Dysplasia ; Tooth Development ; Tooth Eruption
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다운로드국문 초록 (Abstract)
Runx2는 runt gene family에 속하는 전사조절 인자로써 뼈의 형성과 골아세포의 분화에 중요한 역할을 담당하고 있다. Runx2-haploinsufficency는 쇄골의 저형성 및 두개 봉합의 지연을 특징으로 하는 쇄...
Runx2는 runt gene family에 속하는 전사조절 인자로써 뼈의 형성과 골아세포의 분화에 중요한 역할을 담당하고 있다. Runx2-haploinsufficency는 쇄골의 저형성 및 두개 봉합의 지연을 특징으로 하는 쇄골두개 이형성증을 일으키며, 치아에 있어서는 법랑질의 저형성, 영구치 맹출지연 등을 보인다. 이에, 치아의 발육 및 맹출에 미치는 Runx2의 영향을 알아보기 위해 in situ hybridization 방법으로 태생 1, 4, 7, 14. 21일 된 쥐의 하악 및 제1대구치를 사용하여 실험을 실시하였다. Runx2-full length는 태생 1일과 4일에 치낭 및 주위조직에 보이지만 Runx2-typeⅡ는 보이지 않았다. Runx2-full length는 태생 7일에 치관 교합면 부위의 법랑모세포에 발현하였고, 1주일 후인 태생 14일에는 백악법랑경계 상방의 치관인 접면 법랑모세포에서 발현되었다. 이에 반해 Runx2-typeⅡ는 법랑모세포에서 발현하지 않았다. 또한 태생 21일에서는 두가지 이성질체가 모두 하악골에서 발현을 보였다. 이런 결과를 종합해볼 때, Runx2-full length는 치아의 맹출과 연관이 있으며, 법랑모세포의 분화 및 이로 인한 법랑질형성에 영향을 주지만 Runx2-typeⅡ는 하악골의 형성에만 영향을 미치는 것으로 사료된다.
다국어 초록 (Multilingual Abstract)
Runx2 is a transcription factor in homologous with Drosophila runt gene and it is essential for bone formation during embryogenesis and a critical gene for osteoblast differentiation and osteoblast function. Runx2-haploinsufficency causes cleidocrania...
Runx2 is a transcription factor in homologous with Drosophila runt gene and it is essential for bone formation during embryogenesis and a critical gene for osteoblast differentiation and osteoblast function. Runx2-haploinsufficency causes cleidocranial dysplasia (CCD). CCD is an autosomal-dominant inherited disorder characterized by hypoplastic clevicle and delayed ossification in fontanelles and wormian bones. Dental defects are possibly shown to CCD patients : multiple supernumerary teeth, irregular and compressed permanent tooth crowns, hypoplastic and hypomineralized defects in enamel and dentin, an excess of epithelial root remnants, the absence of cellular cementum, and abnormally shaped roots. In addition, delayed eruption of the secondary dentition is a constant finding.
The aim of this study is to evaluate the role of Runx2 in the tooth development and eruption through analyzing the expression pattern of Runx2 by in situ hybridization during crown (late bell stage) and root formation of tooth, using postnatal day 1, 4, 7, 14 and 21 mice mandibular molar teeth. mRNA of Runx2-full length is expressed in dental follicle and surrounding tissue at postnatal day1 and 4. At post-natal day 7, it is expressed in ameloblasts of occlusal surface of enamel and bone area surrounding the tooth. In comparison with previous stage, at postnatal day 14, it is expressed in ameloblasts of proximal surface of enamel. At postnatal day 21 it's expression is observed only in bone area. mRNA of Runx2-typeⅡ is not expressed At postnatal day 1 and 7. At postnatal day 14 and 21, it's expression is observed in the bone area.
In this study, we suggest that Runx2 have a relation of ameloblasts differentiation and an important role to tooth eruption made by dental follicle during intraosseous eruption stage. Also we can confirm that Runx2 has a role to bone formation.
참고문헌 (Reference)
1 "tooth eruption:evidence of the central role of the dental follicle" 9 : 189-200, 1980
2 "The tissue-specific nuclear matrix protein, NMP-2, is a member of the AML/CBF/PEBP2/Runt domain transcription factor family interactions with the osteocalcin gene promotor" 34 : 13125-13132, 1995
3 "The cytology of the dental follicle and adjacent alveolar bone during tooth eruption in the dog" 168 (168): 277-89, 1983
4 "The basic and applied biology of tooth eruption" 32 : 149-157, 1995
5 "Synthesis and secretion of MCP-1 by dental follicle cells-implications for tooth eruption" 78 : 1677-1681, 1999
6 "Spatio-temporal expression patterns of Runx2 isoforms in early skeletogenesis" 34 : 426-433, 2002
7 "Smith's recognizable patterns of human malformation" WB Sanders company 1997
8 "Secretion of CSF-1 and its inhibition in rat dental follicle cells:implication for tooth eruption" 106 : 808-815, 1998
9 "Runx,A multifunctional transcription factor in skeletal development" 87 : 1-8, 2002
10 "Regional control by the dental follicle of alterations in alveolar bone metabolism during tooth eruption" 16 (16): 164-9, 1987
1 "tooth eruption:evidence of the central role of the dental follicle" 9 : 189-200, 1980
2 "The tissue-specific nuclear matrix protein, NMP-2, is a member of the AML/CBF/PEBP2/Runt domain transcription factor family interactions with the osteocalcin gene promotor" 34 : 13125-13132, 1995
3 "The cytology of the dental follicle and adjacent alveolar bone during tooth eruption in the dog" 168 (168): 277-89, 1983
4 "The basic and applied biology of tooth eruption" 32 : 149-157, 1995
5 "Synthesis and secretion of MCP-1 by dental follicle cells-implications for tooth eruption" 78 : 1677-1681, 1999
6 "Spatio-temporal expression patterns of Runx2 isoforms in early skeletogenesis" 34 : 426-433, 2002
7 "Smith's recognizable patterns of human malformation" WB Sanders company 1997
8 "Secretion of CSF-1 and its inhibition in rat dental follicle cells:implication for tooth eruption" 106 : 808-815, 1998
9 "Runx,A multifunctional transcription factor in skeletal development" 87 : 1-8, 2002
10 "Regional control by the dental follicle of alterations in alveolar bone metabolism during tooth eruption" 16 (16): 164-9, 1987
11 "PEBE2/PEA2 represents a new family of transcription fctor homologous to the products of the Drosophila runt and the human AML1 gene" 90 : 659-6863, 1993b
12 "Osf2/Cbfa1:a transcriptional activator of osteoblast differentiation" 89 : 747-754, 1997
13 "Mutation involving the transcription factor Cbfa1 cause CCD" 89 : 773-339, 1997
14 "Histological observations of teeth and peridental tissues in cleidocranial dysplasia imply increased activity of odontogenic epithelium and abnormal bone remodeling" 15 : 212-221, 1995
15 "Histological changes in the bony crypt and gubernacular canal of erupting permanent premolars during deciduous premolar exfoliation in beagles" 53 : 786-791, 1974
16 "Histological and analytical studies of a tooth in a patient with cleidocranial dysostosis" 43 (43): 85-89, 2001
17 "Experimental study in the dog of the non-active role of the tooth in the eruptive process" 29 (29): 311-22, 1984
18 "Enamel knots as signaling centers linking tooth morphogenesis and odontoblast differentiation" 15 : 14-18, 2001
19 "Differential expression patterns of Runx2 isoforms in cranial suture morphogenesis" 16 : 885-892, 2001
20 "Development of the dentition in cleidocranial dysplasia" 19 : 89-93, 1990
21 "Dental treatment strategies in cleidocranial dysplasia" 172 : 243-7, 1992
22 "Dental treatment strategies in cleidocranial dysplasia" 172 (172): 243-7, 1992
23 "Craniofacial abnormalities in 52 school-age and adult patients with cleidocranial dysplasia" 13 : 98-108, 1993
24 "Cementum and other root abnormalities of permanent teeth in cleidocranial dysostosis" 139 : 313-318, 1975
25 "Cellular, molecular, and genetic determinants of tooth eruption" 13 (13): 323-334, 2002
26 "Cbfa1,a candidate gene for CCD syndrome is essential for osteoblast differentiation and bone development" 89 : 765-771, 1997
27 "Cbfa1 in bone development" 8 : 494-499, 1998
28 "Cbfa1 a molecular switch in osteoblast biology" 219 : 461-471, 2000
29 "A histologic study of cementum in a case of cleidocranial dysostosys" 25 : 470-478, 1968
30 "A fundamental transcription factor for bone and cartilage" 276 : 813-816, 2000
Erupted complex odontoma에 의한 하악 제 1대구치 맹출지연
학술지 이력
연월일 | 이력구분 | 이력상세 | 등재구분 |
---|---|---|---|
2027 | 평가예정 | 재인증평가 신청대상 (재인증) | |
2021-01-01 | 평가 | 등재학술지 유지 (재인증) | |
2018-01-01 | 평가 | 등재학술지 선정 (계속평가) | |
2017-12-01 | 평가 | 등재후보로 하락 (계속평가) | |
2013-01-01 | 평가 | 등재학술지 유지 (등재유지) | |
2010-01-01 | 평가 | 등재학술지 유지 (등재유지) | |
2008-01-01 | 평가 | 등재학술지 유지 (등재유지) | |
2006-01-01 | 평가 | 등재학술지 유지 (등재유지) | |
2003-01-01 | 평가 | 등재학술지 선정 (등재후보2차) | |
2002-01-01 | 평가 | 등재후보 1차 PASS (등재후보1차) | |
2001-01-01 | 평가 | 등재후보학술지 선정 (신규평가) |
학술지 인용정보
기준연도 | WOS-KCI 통합IF(2년) | KCIF(2년) | KCIF(3년) |
---|---|---|---|
2016 | 0.39 | 0.39 | 0.37 |
KCIF(4년) | KCIF(5년) | 중심성지수(3년) | 즉시성지수 |
0.36 | 0.35 | 0.399 | 0.05 |