본태눈꺼풀연축 환자에서 보툴리눔독소 주사 후 각막형태검사 변화 = Corneal Topographic Changes after Botulinum Toxin-A Injection in Patients with Essential Blepharospasm

다국어 초록 (Multilingual Abstract)

Purpose: To compare the corneal topographic change before and after botulinum toxin A injection in patients with essential blepharospasm.
Methods: From September 2015 to December 2020, we enrolled total 20 patients, 40 eyes diagnosed with essential blepharospasm.
We estimated the corneal refractive power and astigmatism before and after Nabota® (Daewoong Co. Ltd, Seoul, Korea) botulinum toxin injection at 1 and 3 months using iTrace® Topography (Software version 4.2.1., Tracey technology Inc., Houston, TX, USA). Corneal refractive power was analyzed in superior, inferior, nasal and temporal location at 1 mm, 3 mm zone. Also, steep and flat keratometry, astigmatism was measured by topography.
Results: Corneal refractive power showed significant difference in superior and inferior location of 1 mm zone at 1 month after botulinum toxin injection (p = 0.038, p = 0.042). There was no significant difference in all four locations of 3 mm zone. At 1 month after toxin injection, steep keratometry was only significant reduced (p = 0.046) and with-the-rule astigmatism was shifted to against-the-rule astigmatism. At 3 months after toxin injection, keratometry and astigmatism was resolved to before toxin injection.
Conclusions: At 1 month after Nabota® (Daewoong Co. Ltd) botulinum toxin injection, corneal refractive power at vertical axis was flattened and steep keratometry was significantly reduced. At 3 months after toxin injection, corneal topographic change was changed to before toxin injection.

참고문헌 (Reference)

1 Read SA, "The influence of eyelid morphology on normal corneal shape" 48 : 112-119, 2007

2 문남주 ; 이현일 ; 김재찬, "The Changes in Corneal Astigmatism after Botulinum Toxin-A Injection in Patients with Blepharospasm" 대한의학회 21 (21): 131-135, 2006

3 Bayraktar Bilen N, "Tear meniscus, corneal topographic and aberrometric changes after botulinum toxin-A injection in patients with blepharospasm and hemifacial spasm" 42 : 2625-2632, 2022

4 Robb RM, "Refractive errors associated with hemangiomas of the eyelids and orbit in infancy" 83 : 52-58, 1977

5 Czyz CN, "Long-term botulinum toxin treatment of benign essential blepharospasm, hemifacial spasm, and Meige syndrome" 156 : 173-177, 2013

6 Osaki T, "Impact of botulinum toxin-A on corneal curvature assessed with Scheimpflug and Placido systems" 42 : 750-758, 2016

7 Zhang H, "Evaluation of Scheimpflug imaging parameters in blepharospasm and normal eyes" 18 : 239-, 2018

8 Jankovic J, "Efficacy and safety of incobotulinumtoxinA(NT 201, Xeomin)in the treatment of blepharospasm-a randomized trial" 26 : 1521-1528, 2011

9 Jin KW, "Effects of chalazia on corneal astigmatism : large-sized chalazia in middle upper eyelids compress the cornea and induce the corneal astigmatism" 17 : 36-, 2017

10 Zinkernagel MS, "Effect of upper eyelid surgery on corneal topography" 125 : 1610-1612, 2007

11 Detorakis ET, "Corneal topography in involutional ectropion of the lower eyelid : preoperative and postoperative evaluation" 24 : 431-434, 2005

12 Mansour AM, "Corneal topography after ocular rubbing" 21 : 756-758, 2002

13 Gunes A, "Corneal and tear film changes after botulinum toxin-A in blepharospasm or hemifacial spasm" 34 : 906-910, 2015

14 Mavrikakis I, "Changes in corneal topography with upper eyelid gold weight implants" 22 : 331-334, 2006

15 Lee DH, "Changes in corneal curvature after epiblepharon surgery in children" 29 : e191-5, 2018

16 Holck DE, "Changes in astigmatism after ptosis surgery measured by corneal topography" 14 : 151-158, 1998

17 Kenney C, "Botulinum toxin in the treatment of blepharospasm and hemifacial spasm" 115 : 585-591, 2008

18 Truong DD, "Botulinum toxin : clinical use" 12 : 331-355, 2006