폐암의 Keratin 단백출현에 관한 면역조직화학적 연구 = Immunohistochemical Studies on the Keratin Protein in the Lung Carcinomas

다국어 초록 (Multilingual Abstract)

Lung carcinomas, as defined by WHO criteria, were analyzed by PAP(peroxidase-antipe.oxidase) method with paraffin-embedded sections for the keratin protein. The studies consisted of 30 cases of squamous cell carcinoma (10 cases of well differentiated type, 15 cases of moderately differentiated type and 5 cases of poor)y differentiated type), 3 case of small cell carcinoma and 5 cases of adenocarcinoma.
The results were as follows;
1. The positive reaction of keratin in the lung carcinomas was the strongest in squamous cell carcinoma among the all types.
2. The positive reaction of keratin in the squamous cell carcinonla depended upon the differentiation of tumor cells, showing stronger reaction in the perinuclear and/or pericellular area in the well differentiated type.
3. The positive reaction in the homogeneous intracytoplasmic and/or peripheral area of tumor cells was weakly noted in the adenocarcinoma.
4. The positive reaction of all three small cell carcinoma were absent. The non-neoplastic bronchial mucosae were focally and weakly observed in the bronchial and bronchiolar epithelia.
Therefore, according to the pattern of keratin positive reaction in the lung carcinomas, it was suggested that well differentiated squamous cell carcinoma contained abundant keratin, whereas poorly differentiated squamous cell carcinoma and adenocarcinoma contained less amounts.