도노마이신의 세포 외 배출 및 세포 독성에 미치는 플라보노이드의 효과 = Effect of Flavonoids on Efflux and Cytotoxicity of Daunomycin

다국어 초록 (Multilingual Abstract)

One mechanism which plays a prominent role in development of multi-drug resistance seen in cancer cells is the over-expression of P-glycoprotein (P-gp). It is known that compounds found in vegetables and fruits not only have anticarcinogenic properties but my also modulate P-gp activity. The effect of some dietary components on efflux of dauno-mycin(DNM), a P-gp substrate, was examined in P-gp over-expressed human uterine sarcoma cell line, MES-SA/DX5. The efflux of DNM from the cells was significantly inhibited by quercetin and verapamil. but not by 1-naphthyl-isothiocyanate(NITC). The IC_(50) values for DNM in MES-SA/DX5 cells were increased by flavonoids (quercetin and fisetim), but not by NITC after 72 hour incubation with dietary consituents. In conclusion, flavonoids may play a role in the modulation of P-gp activity in human uterine sarcoma cells.

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