RISS 검색 - 국내학술지논문 상세보기

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다국어 초록 (Multilingual Abstract)

Background
As cases of pneumothorax have been reported in coronavirus disease 2019 (COVID-19) patients, it is suspected as a complication of COVID-19. However, it has not been proven whether COVID-19 is associated with causing pneumothorax by comparing non-COVID-19 pneumonia under mechanical ventilation (MV). The purpose of this study was to evaluate the impacts of COVID-19 on pneumothorax development in mechanically ventilated patients.
Methods
A retrospective cohort study was performed in an intensive care unit (ICU) at tertiary, academic hospital, from February 2020 to March 2021. Occurrence of pneumothorax between COVID-19 and non-COVID-19 pneumonia group was assessed including their baseline clinical characteristics. Risk factors of pneumothorax and association with COVID-19 were analyzed by logistic regression model.
Results
Of the 135 patients, 48 (35.5%) patients were diagnosed with COVID-19. In COVID-19 patients, 30 (63.5%) were male, median age was 66.5 years and 10 (20.8%) developed pneumothorax, which occurred only 4 (4.6%) in non-COVID-19 (P=0.008). Compared to non-COVID-19, COVID-19 patients had lower P/F ratio at ICU admission (84.1 [69.8;126.1] vs. 144 [104.2;217.2], P=0.001) and higher MV settings [positive end expiratory pressure (PEEP) 10.0 [10.0;12.0] vs. 8.0 [6.0;10.0], P=0.001, pressure above PEEP 16.6 ± 5.2, 17.0 ± 4.0, P=0.068]. Co-morbidities tended to be more various in non-COVID19 patients. In the univariate analysis for the risk factors of pneumothorax, PEEP (OR 1.26, P<0.01,) and COVID-19 (OR 5.46, P=0.001) were significantly associated with the development of pneumothorax, where only COVID-19 (OR 14.0, P=0.030) was an exclusive risk factors in the multivariate analysis.
Conclusions
In patients with pneumonia who underwent MV, COVID-19 could be a decisive risk factor on the occurrence of pneumothorax.