Cytotoxic cells : basic mechanisms and medical applications

목차 (Table of Contents)

• CONTENTS
• Contributors = ⅸ
• Preface = xv
• Ⅰ HISTORICAL OVERVIEW
• 1. Molecular Mechanisms of T Cell-Mediated Cytotoxicity / Pierre Golstein = 1
• Ⅱ TARGET CELL RECOGNITION
• 2. MHC Class Ⅰ Interactions in T Cell and Natural Killer Cell Immunity / David H. Margulies ; Doo Hyun Cliung ; Fumito Tani ; Kannan Natarajan = 15
• 3. Antigen Recognition by CD$$8^+$$ CTLs / Denis Hudrisier ; Immanuel F. Luescher = 25
• 4. Murine NK Receptors : Ly-49 Expression. Function, and Intracellular Signaling / John R. Ortaldo ; Daniel W. McVicar = 45
• 5. TCR-Initiated Adhesion and Signaling Cascades in CTL Activation / Matthew F. Mescher ; Paige L. Jensen = 65
• 6. Lysis of Innocent Bystanders by Antigen-Specific Cytotoxic Lymphocytes / Hidefumi Kojima ; Michail V. Sitkovsky = 79
• Ⅲ EFFECTOR CELL SIGNALING PATHWAYS
• 7. Signaling for Cytotoxicity in LGLs / Dragan Jevremovic ; Paul J. Leibson = 87
• 8. Role of Nonimmune Extracellular Signaling Molecules in the Local Tissue Environment During CTL Differentiation and Effector Functions. / Michail V. Sitkovskv ; Sergey G. Apasov = 101
• Ⅳ CYTOTOXIC EFFECTOR MOLECULES
• 9. Overview of Cytotoxic Lymphocyte Effector Mechanisms / Pierre A. Henkurt = 111
• 10. Control of Perforin Gene Expression : A Paradigm for Understanding Cytotoxic Lymphocytes / Mathias G. Lichtenheld = 123
• 11. Perforin : Structure, Biosynthesis, and immune Regulatory Functions / Eckhard R. Podack = 147
• 12. Granule-Mediated Apoptosis : Delivering Death / Christopher J. Froelich = 157
• 13. Granzymes : Mediation of Pro-apoptotic and Nonapoptotic Functions of Cytolytic Lymphocytes and Regulation by Endogenous Intracellular and Circulating Inhibitors / Joseph A. Trapani ; Phillip I. Bird = 179
• 14. Role of Granzymes in Target Cell Lysis and Viral Infections / Markus M. Simon ; Arno M$$\ddot u$$llbacher = 197
• 15. Granulysin and NK-Lysin : Cytotoxic and Antimicrobial Proteins of Cytolytic Lymphocytes / Dennis A. Hanson ; Alan M. Krensky = 213
• 16. TCR-Induced Signaling for Cytotoxicity : Regulation of CD951 (Fas Ligand) Expression in Activated T Lymphocytes / Lyse A. Norian ; Gary A. Koretzky = 229
• 17. Transcriptional Regulation of the FasL Gene / Alicia Algeciras-Schimnich ; Carlos V. Paya = 239
• Ⅴ CYTOTOXIC LYMPHOCYTES IN VIVO
• 18. Perforin-Dependent Cytotoxicity in Autoimmunity and Antiviral Resistance / David K$$\ddot a$$gi = 249
• 19. Cytotoxic Lymphocytes in Hepatitis B / Barbara Rehermann = 257
• 20. Cytotoxic T-Cell Responses to Intracellular Pathogens / Steffen Stenger ; Robert L. Modlin = 269
• 21. Tumor Surveillance In Vivo Depends on Perforin-Mediated Cytolysis / Manes F. van den Broek ; David K$$\ddot a$$gi ; Hans Hengartner = 281
• 22. Role of Fas-Dependent Lytic Function in In Vivo Immune Regulation and Pathogenesis / Kimberly A. Sabelko-Downes ; Anja R. B. Thilenius ; Kathleen A. Kelly ; John H. Russell = 289
• Ⅵ CTL GENERATION AND MEMORY
• 23. Helping Killers / John Paul Ridge ; Francesca Di Rosa ; Polly Matzinger = 303
• 24. Cytotoxic T Cell Memory / Arno M$$\ddot u$$llbacher ; Robert V. Blanden = 317
• 25. CD8 Memory to Viruses and the T Cell Network / L$$\ddot u$$sa K. Selin ; Meei Y. Lin ; Steven M. Varga ; Raymond M. Welsh = 327
• Ⅶ MEDICAL APPLICATIONS OF CYTOTOXIC LYMPHOCYTES
• 26. Tumor Antigens Recognized by Cytotoxic Lymphocytes / Paul F. Robbins ; Rong-Fu Wang ; Steven A. Rosenberg = 363
• 27. Manipulation of T Cell Activation to Generate Antitumor CTLs / Arthur A. Hurwitz ; Andrea van Elsas ; Dana R. Leach ; Jennifer Ziskin ; Jennifer Villasenor ; Tan Truong ; James P. Allison = 385
• 28. Use of Bacterial DNA in Vaccines for CTL Generation / Grayson B. Lipford ; Hermann Wagner = 395
• 29. Redirected Cellular Cytotoxicity / David M. Segal ; Stuart W. Hicks ; Alessandra Mazzoni ; Alberto Visintin = 405
• 30. Clinical Applications of Redirected Cytotoxicity / Reinder L. H. Bolhuis ; Ralph A. Willemsen ; Jan W. Gratama = 423
• 31. Cytotoxic T Lymphocyte Adoptive Immunotherapy for HIV Infection / Judy Lieberman = 441
• Subject Index = 459