3차원 PDMS 구조제작에 관한 연구

다국어 초록 (Multilingual Abstract)

Polydimethylsiloxane (PDMS) is the most promising material which can be used in areas such as microfluidic systems, biomedical devices because it has useful properties such as good thermal stability, biocompatibility, corrosion resistance, flexibility, low cost, ease of use, chemically inertia, and gas permeability. However, it has the surfaces with strong hydrophobicity which can prevent binding of biomolecules and cells. Thus, its inherent hydrophobicity has acted as a deterrent for further development and commercialization in biomedicine. Previous research about porous PDMS membrane evaluated by measuring the adhesion of various biomolecules and bioactivity of cells and showed significant improvement over conventional non-porous PDMS membrane. Currently, there are many studies about 3D shape of membrane like spheroid, but they have many problems due to difficulties of cell growing. In this study, not only used the PDMS membrane also experiment for pore size and thickness compared by RPM(4500, 5000, 5500, 6000). As a result, it was observed that the thickness became thinner as the RPM increased. These results can be applied to research on hemispherical experiment or various shapes membrane experiment.

목차 (Table of Contents)

• 1. 서론 1
• 1.1 PDMS 1
• 1.1.1 PDMS의 역사 2
• 1.1.2 PDMS의 화학적 구조와 특성 3
• 1.2 다공성 PDMS멤브레인에 대한 제작 기술 리뷰 6
• 2. 실험 재료 및 실험 방법 10
• 2.1 실험 재료 10
• 2.1.1 PDMS 10
• 2.1.2 20G needle 12
• 2.1.3 Si wafer 18
• 2.2 실험방법 19
• 2.2.1 PDMS 마스크 제작 및 패터닝 19
• 2.2.5 광학현미경을 이용한 membrane 분석 30
• 3. 실험 결과 및 고찰 31
• 3.1 반구형 PDMS 다공성 membrane 31
• 3.2 RPM별 반구형 PDMS 다공성 membrane의 pore 크기 33
• 3.3 RPM별 반구형 PDMS 다공성 membrane의 두께 39
• 3.4 RPM별 반구형 PDMS 다공성 membrane의 투과성 42
• 4. 결론 44