Studies on the underlying mechanisms for the paradoxic role of NGF in a glucose-deficient condition = 포도당 결핍시 나타나는 NGF의 이율배반적 인 기능에 대한 기저 메카니즘 연구

다국어 초록 (Multilingual Abstract)

Temporal changes in the level of unbound intracellular calcium(Ca) were investigated over 24h in pheochromocytoma cells (PC12) cultured in either serum- or glucose-free conditions both serum deprivation and glucose deprivation led to a dramatic increase in cytoplasmic Ca up to 2h after the onset of deprivation. The Ca level that once reached to a peak decreased to normal within 2h in serum deprivation case while that Ca level elevated by glucose deprivation did not decrease at all for several hours (at least 6h). Intracellular Ca remained elevated over 24h in glucose deprivation. Ryanodine but not nifedipine could prominently black the Ca rises by glucose deprivation, suggesting that a Ca release from intracellular Ca stores may be a major source for raising Ca intracellularly in the lack of energy supply

목차 (Table of Contents)

• Long-tern Changes in the Level of Intracellular Calcium of Naive PC12 Cells after Ghcose Withdrawal
• 1.ABSTRACT
• 2.INTRODUCTION
• 3.METERIALS AND METHODS
• 4.RESULTS
• 5.DICUSSION
• 6.ACKNOWLEDGMENT
• 7.REFERENCES
• Calcium as a Potential Candidate for an NGF-enhanced Cytetexicity
• 1.CONCLUDING REMARK
• 2.ACKNOWLEDGMENT
• 3.REFERENCES
• NGF-induced cytotoxicity in PC12 cells in a hypogoycemic environment
• 1.INTRODUCTION
• 2.METERIALS AND METHODS
• 3.RESULTS
• 4.DICUSSION
• 5.conclusion
• 6.REFERENCES