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The influence of 5-hdroxytryptamine and / or cyproheptadine on the action of ouabain was investigated in the isolated frog heart or in the whole fros. 1. LD_50 of ouabain was 2.88㎍/10g in control group. 2. Low doses(100 or 300 ㎍/10g) of 5-hydroxyt...
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RISS 인기검색어
개구리 心臟에서 Ouabain 效果에 미치는 Serotonin의 影響 = Influence of Serotonin on the Effect of Ouabain in Frogs
한글로보기https://www.riss.kr/link?id=A19689965
- 저자
- 발행기관
- 학술지명
- 권호사항
-
발행연도
1989
-
작성언어
Korean
-
KDC
510.000
-
자료형태
학술저널
-
수록면
135-141(7쪽)
- 제공처
- 소장기관
-
0
상세조회 -
0
다운로드
부가정보
다국어 초록 (Multilingual Abstract)
The influence of 5-hdroxytryptamine and / or cyproheptadine on the action of ouabain was investigated in the isolated frog heart or in the whole fros.
1. LD_50 of ouabain was 2.88㎍/10g in control group.
2. Low doses(100 or 300 ㎍/10g) of 5-hydroxytryptamine increased LD_50 of ouabain, but high dose of the drug decreased LD_50 of ouabain. However, the effect of 5-hydroxytryptamine was blocked by cyproheptadine.
3. Ouabain induced dose-dependent biphasic response ; at low doses(10^-7-10^-6M) ouabain decreased contractile force of myocardium, while high doses of the drug(above 3X10^-6M) increased oncractile force as well as decrease of heart rate.
4. 5-hydroxytryptamine inhibited the negative inotrophic and bradycardiac effects of ouabain, but cyproheptadine did not affect the effects of 5-hydroxytryptamine.
From the above results, it is suggested that there are two dose-related ouabain-sensitive sites in frog heart, and bradycardiac effect of ouabain is different from that of extracardiac regions.
1. LD_50 of ouabain was 2.88㎍/10g in control group.
2. Low doses(100 or 300 ㎍/10g) of 5-hydroxytryptamine increased LD_50 of ouabain, but high dose of the drug decreased LD_50 of ouabain. However, the effect of 5-hydroxytryptamine was blocked by cyproheptadine.
3. Ouabain induced dose-dependent biphasic response ; at low doses(10^-7-10^-6M) ouabain decreased contractile force of myocardium, while high doses of the drug(above 3X10^-6M) increased oncractile force as well as decrease of heart rate.
4. 5-hydroxytryptamine inhibited the negative inotrophic and bradycardiac effects of ouabain, but cyproheptadine did not affect the effects of 5-hydroxytryptamine.
From the above results, it is suggested that there are two dose-related ouabain-sensitive sites in frog heart, and bradycardiac effect of ouabain is different from that of extracardiac regions.
The influence of 5-hdroxytryptamine and / or cyproheptadine on the action of ouabain was investigated in the isolated frog heart or in the whole fros.
1. LD_50 of ouabain was 2.88㎍/10g in control group.
2. Low doses(100 or 300 ㎍/10g) of 5-hydroxytryptamine increased LD_50 of ouabain, but high dose of the drug decreased LD_50 of ouabain. However, the effect of 5-hydroxytryptamine was blocked by cyproheptadine.
3. Ouabain induced dose-dependent biphasic response ; at low doses(10^-7-10^-6M) ouabain decreased contractile force of myocardium, while high doses of the drug(above 3X10^-6M) increased oncractile force as well as decrease of heart rate.
4. 5-hydroxytryptamine inhibited the negative inotrophic and bradycardiac effects of ouabain, but cyproheptadine did not affect the effects of 5-hydroxytryptamine.
From the above results, it is suggested that there are two dose-related ouabain-sensitive sites in frog heart, and bradycardiac effect of ouabain is different from that of extracardiac regions.
동일학술지(권/호) 다른 논문
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實驗的 高血壓 白鼠의 心脈管系 機能調節에 있어서 中樞 Opiate System의 役割
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