산수유 씨의 최종당화산물 생성저해활성 성분 = Constituents of the seeds of Cornus officinalis with Inhibitory Activity on the Formation of Advanced Glycation End Products (AGEs)

다국어 초록 (Multilingual Abstract)

Ten compounds, (+)-pinoresinol (1), (–)-balanophonin (2), gallicin (3), vanillin (4), 4-hydroxybenzaldehyde
(5), coniferaldehyde (6), betulinic acid (7), ursolic acid (8), 5-hydroxymethyl furfural (9),
and malic acid (10), were isolated from a EtOAc-soluble fraction of the seeds of Cornus officinalis.
The structures of these compounds were elucidated by spectroscopic methods as well as by comparison
with reported values. Compounds 1, 2, and 4-7 were isolated from this species for the first
time. All the isolates (1-10) were subjected to an in vitro bioassay to evaluate their inhibitory activity
against advanced glycation end products (AGEs) formation. Among these, compounds 2 and 3
showed the significant inhibitory activity on AGEs formation with IC50 values of 27.81 and 18.04
μM, respectively.

다국어 초록 (Multilingual Abstract)

Ten compounds, (+)-pinoresinol (1), (–)-balanophonin (2), gallicin (3), vanillin (4), 4-hydroxybenzaldehyde
(5), coniferaldehyde (6), betulinic acid (7), ursolic acid (8), 5-hydroxymethyl furfural (9),
and malic acid (10), were isolated from a EtOAc-soluble fraction of the seeds of Cornus officinalis.
The structures of these compounds were elucidated by spectroscopic methods as well as by comparison
with reported values. Compounds 1, 2, and 4-7 were isolated from this species for the first
time. All the isolates (1-10) were subjected to an in vitro bioassay to evaluate their inhibitory activity
against advanced glycation end products (AGEs) formation. Among these, compounds 2 and 3
showed the significant inhibitory activity on AGEs formation with IC50 values of 27.81 and 18.04
μM, respectively.

참고문헌 (Reference)

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