20–39세 성인 비만 남성에서 혈청 남성호르몬 농도에 영향을 미치는 인자 = Factors Associated with Serum Testosterone Levels in Obese Men Aged 20–39 Years

다국어 초록 (Multilingual Abstract)

Background: Reportedly, obesity is associated with low testosterone levels in men; however, very few studies have assessed obesity and lowtestosterone levels in young men. This study aimed to investigate factors associated with serum testosterone level in young obese men aged 20–39years.
Methods: A total of 270 participants aged 20–39 years were recruited via the out-patient clinic of a university hospital for weight managementbetween 2017 and 2020. All participants underwent anthropometric measurement, bioelectrical impedance analysis, and blood tests. Wecompared serum total testosterone levels and other factors using Pearson’s correlation coefficient and a multiple linear regression model.
Results: There was significant negative correlation between serum testosterone levels and waist circumference (r=-0.390, P<0.001), body massindex (r=-0.305, P<0.001), and body fat percent (r=-0.286, P<0.001). Independently, serum testosterone levels were significantly associated withwaist circumference (β=-0.046, P=0.002), serum alanine aminotransferase (ALT) levels (β=-0.399, P=0.005), and serum triglyceride levels (β=-0.501, P<0.001) after linear regression model adjustments.
Conclusion: Low serum total testosterone level was independently associated with waist circumference, serum triglyceride, and ALT level in youngobese men.

국문 초록 (Abstract)

연구배경: 젊은 성인 남성에서 비만과 남성호르몬의 관련성에 대한연구는 부족하다. 본 연구는 국내 1개 병원에서 3년간 비만치료를위해 외래 방문한 20–39세 남성 비만 환자들의 혈청 남성호르몬 농도에 영향을 미치는 인자가 무엇인지 알아보고자 하였다.
방법: 외래 초진기록을 통해 환자의 과거력(고혈압, 당뇨병, 고지혈증 등) 및 약물복용력, 운동, 흡연, 음주 유무를 조사하였다. 자동신체 계측기로 측정한 신장과 체중을 이용하여 체질량지수(kg/m2)를 계산하였다. 허리둘레는 직립자세에서 늑골의 최하단부와 엉덩뼈능선 최상단부의 중간 지점에서 가볍게 숨을 내쉰 상태에서 측정되었다. 체지방률은 Inbody 720 (Biospace, Korea)을 사용하여 측정하였다.
결과: 총 270명의 20–39세 남성 비만 환자들이 연구에 참여하였다.
연구대상자들의 평균 체중은 100.4±15.4 kg이었으며 피어슨 상관계수 분석에서 총 남성호르몬 농도와 체질량지수, 수축기혈압, 이완기혈압, 허리둘레, 체지방량, 당화혈색소, 혈당, ALT, 중성지방이 음의상관관계를, 고밀도지단백질이 양의 상관관계를 보였다. 통계적으로유의한 상관관계를 보인 변수들을 독립변수로 다중 선형회귀분석을 시행하였고, 허리둘레(모델 3, β=-0.046, P=0.002), ALT (모델 3,β=-0.399, P=0.005), 중성지방(모델 3, β=-0.501, P<0.001)이 총 남성호르몬 농도 저하에 영향을 주는 독립변수들로 나타났다.
결론: 젊은 비만 남성에서 남성호르몬의 감소는 허리둘레와 중성지방 및 ALT와 독립적인 연관성이 관찰되었다.

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